Results 121 to 130 of about 962,136 (301)
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Frontiers in EducationThis study develops a hybrid Project-Based Learning (PBL) model integrating online-offline instruction for Hydraulic and Pneumatic Transmission. Using an intelligent tractor leveling system case, we implemented the approach with 93 undergraduates (test ...
Jiaxin Wang +5 more
doaj +1 more source
, 1959 Video footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about the last steam-driven train leaving the Niles City Train Depot in Tarrant ...
WBAP-TV (Television station : Fort Worth, Tex.)
core
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
, 1959 Video footage from the WBAP-TV television station in Fort Worth, Texas, to accompany a news story about two train drivers, who wrecked the train while they were switching freight cars while they were drunk on private ...
WBAP-TV (Television station : Fort Worth, Tex.)
core
Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids
FEBS Open Bio, EarlyView.Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão +3 more
wiley +1 more source
Rock Hill Train Station Photograph - Accession 500 - M209 (251)
, 2015 The Rock Hill Train Station Photograph depicts the Train Depot in Rock Hill, SC ca1970s before it was torn down.https://digitalcommons.winthrop.edu/manuscriptcollection_findingaids/1634/thumbnail ...
Rock Hill Train Station
core +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1
FEBS Open Bio, EarlyView.The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay +2 more
wiley +1 more source