Results 91 to 100 of about 1,435,170 (249)
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Neural networks as a control methodology [PDF]
While conventional computers must be programmed in a logical fashion by a person who thoroughly understands the task to be performed, the motivation behind neural networks is to develop machines which can train themselves to perform tasks, using ...
Mccullough, Claire L.
core +1 more source
Innovative Research and Implementation of High-speed Train Network Control System for CRH2
机车电传动, 2014 CRH2 high-speed train network topology and train transport protocol were introduced, and independent high-speed train network control software system architecture and network control system logic functions was described in detail.
HUO Fang, LIU Qun-xin, ZHANG Sen
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Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
On structuring the rules of a fuzzy controller [PDF]
Since the pioneering work of Zadeh and Mamdani and Assilian, fuzzy logic control has emerged as one of the most active and fruitful research areas. The applications of fuzzy logic control can be found in many fields such as control of stream generators ...
Raju, G. V. S., Zhou, Jun
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Application of PHM Technology on LKJ-15C Train Operation Control System
Kongzhi Yu Xinxi Jishu, 2018 The maintenance cost of the LKJ train operation control system is high and the spair part supply is difficult to manage. This paper introduces PHM technology to railway train operation control system.
SUN Zeyong, ZHOU Zhifei
doaj
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Research on the Driving Mode Conversion for CBTC System Based onTrain-to-train Communication
Kongzhi Yu Xinxi Jishu, 2021 Unattended operation CBTC (communication based train control) system based on train-to-train communication is the main research direction of the next generation urban rail transit train control system, which provides a various of driving modes. According
ZHENG Yi, SHEN Tao, SUN Ye, SUN Ke
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