Results 31 to 40 of about 221,320 (301)
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Chengshi guidao jiaotong yanjiu[Objective] The architecture of traditional urban rail transit train control system faces challenges such as complex train network topology and wiring, increased delays in subsystem interactions, and poor coordination in complex control processes.
YANG Weijun +5 more
doaj +1 more source
An Unscented Kalman Filter-based Synchronization Control Approach for Communication-Based Train Control Systems [PDF]
, 2019 Communication-based train control (CBTC) system is an advanced train signalling and control technology which is developed using the moving block signalling (MBS) framework.
Widyotriatmo, Augie; Instrumentation and Control Research Group, Institut Teknologi Bandung, Bandung 40142, Indonesia +4 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
City Railway Train Control System Key Management Technology
Chengshi guidao jiaotong yanjiu[Objective] In response to the issues in city railway train control systems， such as the insufficient security， operational complexity， and low cross-domain running efficiency associated with the offline management of vehicle-wayside communication ...
WANG Lu +5 more
doaj +1 more source
Analysis and prospect of communication technology in smart urban rail
Dianxin kexue, 2021 The particularity of the urban rail transit environment leads to the problems such as reducing communication reliability, delay performance and operating efficiency bottlenecks.Therefore, the demand for urban rail communication was analyzed from the ...
Junhui ZHAO, Danyang ZHANG, Lin HE
doaj
Future Train Control Systems: Challenges for Dependability Assessment
, 2022 The prospected advent of advanced train control systems, such as moving block and virtual coupling, raises the issue of the effects that uncertainty on critical parameters (such as position or speed) can have on dependability. Several approaches to the evaluation of such effects have been proposed, typically based on a state-based formal modelling of ...
Alessandro Fantechi +2 more
openaire +3 more sources