Results 61 to 70 of about 221,320 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparative Analysis of the Operation Control System for High-speed Maglev and the CBTC Signal System for Metro

Kongzhi Yu Xinxi Jishu, 2018
The backbone of high-speed maglev system is the operation control system (OCS), which is responsible for train control and operation safety. In order to provide theoretical basis for further research and to better understand the key features of OCS ...
WU Weiping, HU Jian, GAO Yuan
doaj  

Autonomous Train Control System Principle: Fully Train‐Centric Route Generation and Track Resource Management

IET Intelligent Transport Systems
The current moving block systems still depend on wayside interlocking systems and zone controllers, resulting in complex control flow and limited control efficiency.
Sehchan Oh, Kyungran Kang, Young‐Jong Cho   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Study on Application Solution of Moving Block in Heavy Haul Railway

机车电传动, 2020
Based on the analysis of existing blocking system and train control mode of heavy haul railway, combined with current application of moving block, the key points and difficult problems of heavy haul railway adopting moving block were analyzed.
Feng LI
doaj  

Current status analysis and countermeasure exploration for train communication network security

机车电传动, 2023
With the in-depth application of Ethernet technology in the train networked control system, the train communication network is facing increasing cybersecurity challenges.
ZOU Zhirong, CHEN Chaoqun, CHEN Bo, TANG Pin   +3 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Research on the Solution of Train-trackside CooperativeShortening Movement Authority

Kongzhi Yu Xinxi Jishu, 2020
In railway operations, when an opened route needs to be closed occasionally, the approach locking function of interlocking is needed to avoid the trip risk of a train.
LI Qihe
doaj  

CATEGORIZATION OF CYBER TRAINING ENVIRONMENTS FOR INDUSTRIAL CONTROL SYSTEMS [PDF]

, 2017
First responders and professionals in hazardous occupations undergo intense training and evaluation to enable them to efficiently and effectively mitigate risk and damage. For example, helicopter pilots train with multiple simulations that increase in complexity before they fly real aircraft.
Evan Plumley, Mason Rice, Stephen Dunlap, John M. Pecarina   +3 more
openaire   +2 more sources

Intelligent rail crossing control system and train tracking system

, 1998
An intelligent intersection control system features an internal controller that receives digital messages containing detailed information items concerning, for example, the direction, speed, length and identity of a train.
Roop, Stephen S., Ruback, Leonard G.
core