Results 71 to 80 of about 10,426,457 (341)
Hypoxic training increases maximal oxygen consumption in Thoroughbred horses well-trained in normoxia. [PDF]
, 2017 Hypoxic training is effective for improving athletic performance in humans. It increases maximal oxygen consumption (V̇O2max) more than normoxic training in untrained horses. However, the effects of hypoxic training on well-trained horses are unclear. We
Jones, James H +4 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Frontiers in Veterinary ScienceIntroductionVeterinary professionals have a key role in facilitating multi-agency collaboration to prevent and respond to domestic violence (DV) in situations where animals may be directly or indirectly involved.
Rochelle Paterson +4 more
doaj +1 more source
An Analysis of the Effectiveness of Training Sociodynamic Counseling in Improving the Communication Skills of the Librarians of Khomeini Shahr\'s Public Libraries [PDF]
تحقیقات اطلاعرسانی و کتابخانههای عمومی, 2020 Purpose: According to Scharf (2013), the library profession is one of the professions in which communication plays an important role. In other words, not only the quantity and quality of library equipment are effective in attracting the client to the ...
Marzieyh Malekiha, Zahra Shahgholi
doaj
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Training Grounds: Training and…Travel
Theatre, Dance and Performance Training, 2013 February 2012. Research trip to Bosnia and Herzegovina. It is snowing when I visit Sarajevo War Theater. Up a steep hill not far from the Zetra Stadium. Where Torvill and Dean danced to Bolero in 1984. Old people struggle to stay on their feed. Children zoom downhill on handmade sledges. A young man clears the snow from the theatre's doorway. I ask him
openaire +2 more sources
Sports Injury Prevention and Functional Training: A Literature Review [PDF]
, 2021 Ki‐Kwang Lee, Kwang-Jin Lee
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source