Results 41 to 50 of about 1,457,117 (258)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Role of Gender-Based Emotional Intelligence in Corporate Financial Decision-Making

Psychology Research and Behavior Management, 2021
Zou Ran,1,2 Azeem Gul,3 Ahsan Akbar,4 Syed Arslan Haider,5 Asma Zeeshan,6 Minhas Akbar7 1Kunming LIH SkyCity Rehabilitation Hospital, Kunming, People’s Republic of China; 2Faculty of Education, Segi University, Kuala Lumpur, Malaysia; 3Department of ...
Ran Z, Gul A, Akbar A, Haider SA, Zeeshan A, Akbar M   +5 more
doaj  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Common perinatal mental disorders in northern Viet Nam: community prevalence and health care use

Bulletin of the World Health Organization, 2010
OBJECTIVE: To establish the prevalence of common perinatal mental disorders their determinants, and their association with preventive health care use among women in one rural and one urban province in northern Viet Nam.
Jane Fisher, Thach Tran, Buoi thi La, Kelsi Kriitmaa, Doreen Rosenthal, Tuan Tran   +5 more
doaj  

Investigating the Level of Mathematics Anxiety among Junior High School Pupils

MEJ (Mathematics Education Journal)
Mathematics is a fascinating and perplexing subject that is constantly evolving in a variety of scientific fields. Naturally, it is amazing and beautiful to use mathematics to solve a real-life problem and comprehend it.
David Koomson, Francis Ohene Boateng, Ebenezer Kwesi Lotey   +2 more
doaj   +1 more source

Retention Issues in Banking Industry of Pakistan: A Case Study of Habib Metro and Soneri Bank

JISR Management and Social Sciences & Economics, 2013
Every growing organization considers its human resource as the most precious and critical asset. Hence the importance of retention management in the organizations is very important. The world of banking has changed radically since last decade. In banks,
Amin Anwer Rashidi, Mustaghis ur Rahman
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Training and development [PDF]

Journal of the American Dietetic Association, 1994
The changing perception of the nature of managerial jobs has had profound implications for management trainers and developers. Some managers′ role has evolved from task managers to people and role player. Trainers can no longer rely solely on provision of the task‐related management training; rather they are expected to become familiar with people ...
openaire   +2 more sources

Towards improved maternal health: Navigating non-compliance with integrated viral hepatitis B and malaria interventions among pregnant women in Bono East, Ghana.

Heliyon
Background: Effective management of viral hepatitis B (HBV) and malaria in pregnancy requires compliance with HBV vaccination, long-lasting insecticidal nets (LLINs), and intermittent preventive treatment in pregnancy with sulfadoxine-pyrimethamine (IPTp-
Dennis Bardoe, Daniel Hayford, Robert Bagngmen Bio, Denis Dekugmen Yar, Ernest Osei, Ismail Coffie, Mohammed Zakaria, Francisca Serwaa Oppong, Fiave John Bosco, George Ahiaka, Enoch Owusu Yeboah, Samuel Mengyah, Frank Mengyah   +12 more
doaj   +1 more source