Results 201 to 210 of about 716,573 (292)

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Crowdsourced biodiversity monitoring fills gaps in global plant trait mapping. [PDF]

Nat Commun
Lusk D, Wolf S, Svidzinska D, Dormann CF, Kattge J, Bruelheide H, Sabatini FM, Damasceno G, Moreno Martínez Á, Violle C, Hending D, Hähn GJA, Tabeni S, Phartyal S, Gonçalves F, Kreft H, Schmidt M, Chen H, Güler B, Dolezal J, Pielech R, Guido A, Dwyer C, Napoleone F, Willie J, Gasper AL, Macía MJ, Chytry M, Lenoir J, Thakur D, Dengler J, Świerszcz S, Altman J, Mucina L, Nerlekar AN, Kakinuma K, Rawat P, Stančić Z, Testolin R, Hatim MZ, Rodrigues F, Homeier J, Marques MCM, McCarthy JK, El-Sheikh MA, Korznikov K, Gerberding K, Kattenborn T.   +47 more
europepmc   +1 more source

Single‐Cell Atlas of Subchondral Bone Marrow Lesions Reveals Proteostasis Dysfunction as a Druggable Mechanism for Early Osteoarthritis

Advanced Science, EarlyView.
This study reveals that abnormal mechanical stress downregulates the expression of HSP70 and impairs proteasome function in osteoarthritic bone cells, leading to misfolded collagen I accumulation and ER stress. When intracellular proteostasis capacity is exceeded, USP19 mediates the secretion of misfolded proteins into the extracellular space ...
Hailun Xu, Ting He, Yu Qian, Jia Li, Bowei Ni, Xiaojie Xu, Huanbo Wang, Peng Wang, Guoqing Cao, Siqi Ying, Guangyu Ding, Rong Wang, Zenghui Gu, Wei Li, Zhentao Man, Houfeng Zheng, Zhaohua Zhu, Zhen Li, Qingjun Meng, Chao Zheng, Liu Yang   +20 more
wiley   +1 more source

Fast and flexible joint fine-mapping of multiple traits via the Sum of Single Effects model. [PDF]

Nat Genet
Zou Y, Carbonetto P, Xie D, Wang G, Stephens M.   +4 more
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Differences in extinction selectivity and their relationship to functional traits in late Cenozoic mollusks. [PDF]

PeerJ
Rojas-Ariza D, Strotz LC, Lieberman BS.
europepmc   +1 more source

Parental and environmental determinants of larval dispersal-associated traits and post-settlement physiology

, 2021
Daphne Cortese
openalex   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

The primacy of species turnover over intraspecific variation in the environmental filtering of understory ferns. [PDF]

Front Plant Sci
Zhou Y, Zhang Z, Liu H, Jiang S, Zheng Z, Shen G, Wang X, Yang Q.   +7 more
europepmc   +1 more source

Systematic Mapping Study of Tools to Identify Emotions and Personality Traits [PDF]

Amanul Islam, Nurul Fazmidar Binti Mohd Noor, Siti Soraya Abdul Rahman   +2 more
openalex   +1 more source