Results 51 to 60 of about 840,036 (267)

A Latent Variable Approach to Multivariate Quantitative Trait Loci [PDF]

, 2010
A novel approach based on latent variable modelling is presented for the analysis of multivariate quantitative and qualitative trait loci. The approach is general in the sense that it enables the joint analysis of many kinds of quantitative and ...
Päivi Komulainen, Outi Savolainen, Mikko J. Sillanpää, Bob O'Hara   +3 more
core  

A Bayesian approach to detect QTL affecting a simulated binary and quatitative trait [PDF]

, 2011
Background - We analyzed simulated data from the 14th QTL-MAS workshop using a Bayesian approach implemented in the program iBay. The data contained individuals genotypes for 10,031 SNPs and phenotyped for a quantitative and a binary trait. Results - For
Janss, L.L.G., Heuven, H.C.M., Geneeskunde van gezelschapsdieren, Advances in Veterinary Medicine, Bouwman, A.C., Aniek C Bouwman, Henri CM Heuven, Luc LG Janss   +7 more
core   +2 more sources

The genetic landscape of human functional brain connectivity

Nature Communications
Investigating the genetic underpinnings of functional brain connectivity is essential to understand how genetic variation influences brain health and disease.
Bernardo de APC Maciel, Marijn Schipper, Cato Romero, Christiaan de Leeuw, Koen Helwegen, Danielle Posthuma, Jeanne E. Savage, Martijn P. van den Heuvel   +7 more
doaj   +1 more source

Functional mapping and annotation of genetic associations with FUMA

Nature Communications, 2017
Prioritizing genetic variants is a major challenge in genome-wide association studies. Here, the authors develop FUMA, a web-based bioinformatics tool that uses a combination of positional, eQTL and chromatin interaction mapping to prioritize likely ...
Kyoko Watanabe, Erdogan Taskesen, Arjen van Bochoven, Danielle Posthuma   +3 more
doaj   +1 more source

Pyramiding of transcription factor, PgHSF4, and stress-responsive genes of p68, Pg47, and PsAKR1 impart multiple abiotic stress tolerance in rice (Oryza sativa L.)

Frontiers in Plant Science, 2023
Abiotic stresses such as drought, salinity, and heat stress significantly affect rice crop growth and production. Under uncertain climatic conditions, the concurrent multiple abiotic stresses at different stages of rice production became a major ...
H. S. Sheela, Amaranatha R. Vennapusa, Amaranatha R. Vennapusa, Kalpalatha Melmaiee, T. G. Prasad, Chandrashekar P. Reddy   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study-5

, 2011
Dot indicates a yeast segregant of which the allele of marker block 348 is inherited from BY (RM) strain.Copyright information:Taken from "Trait-trait dynamic interaction: 2D-trait eQTL mapping for genetic variation study"http://www.biomedcentral.com ...
Ker-Chau Li (41341), Wei Sun (93580), Shinsheng Yuan (41343)   +2 more
core   +1 more source

The confirmability and disconfirmability of trait concepts revisited: does content matter? [PDF]

, 2007
M. Rothbart and B. Park (1986) demonstrated that, consistent with the common negativity bias, positive traits are difficult to confirm and easy to disconfirm, whereas the opposite is true for negative traits.
Kenworthy, Jared B., Hewstone, Miles, Hewstone, M, Tausch, Nicole, Tausch, N, Kenworthy, JB, Hewstone, M., Kenworthy, J.   +7 more
core   +1 more source

Shifts in biomass and structure of habitat‐formers across a latitudinal gradient

Ecology and Evolution, 2021
Global patterns of plant biomass drive the distribution of much of the marine and terrestrial life on Earth. This is because their biomass and physical structure have important consequences for the communities they support by providing food and habitat ...
Talia Peta Stelling‐Wood, Alistair G. B. Poore, Paul E. Gribben   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source