Results 41 to 50 of about 481,673 (265)
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
The genetic landscape of human functional brain connectivity
Nature CommunicationsInvestigating the genetic underpinnings of functional brain connectivity is essential to understand how genetic variation influences brain health and disease.
Bernardo de APC Maciel +7 more
doaj +1 more source
Diversity, 2023 Periphytic rotifer assemblages from lentic habitats are understudied. To improve knowledge on the principal environmental determinants of their structure and composition, we examined summer periphyton from 184 freshwater bodies from a taxonomic and multi-
Luc Denys, Willem H. De Smet
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Functional mapping and annotation of genetic associations with FUMA
Nature Communications, 2017 Prioritizing genetic variants is a major challenge in genome-wide association studies. Here, the authors develop FUMA, a web-based bioinformatics tool that uses a combination of positional, eQTL and chromatin interaction mapping to prioritize likely ...
Kyoko Watanabe +3 more
doaj +1 more source
Frontiers in Ecology and Evolution, 2023 In the face of rapid environmental changes, understanding and monitoring biological traits and functional diversity are crucial for effective biomonitoring. However, when it comes to freshwater macroinvertebrates, a significant dearth of biological trait
Shuyin Li +4 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Plant Science, 2023 Abiotic stresses such as drought, salinity, and heat stress significantly affect rice crop growth and production. Under uncertain climatic conditions, the concurrent multiple abiotic stresses at different stages of rice production became a major ...
H. S. Sheela +5 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source