Urine-Derived iPSC Neurospheres Uncover Proteomic Correlates of Clinical Severity in Dravet Syndrome. [PDF]
Urine epithelial cells from Dravet syndrome (DS) patients carrying distinct SCN1A variants were reprogrammed into induced pluripotent stem cells (iPSCs) and differentiated into neural stem cells (NSCs) to generate patient‐derived neurospheres. Three neurosphere lines were analyzed in biological triplicates using isobaric quantitative proteomics ...
Martins M +9 more
europepmc +2 more sources
Isometric handgrip contraction increases tibialis anterior intrinsic motoneuron excitability in a dose-dependent manner. [PDF]
Abstract The contribution of persistent inward currents (PICs) to motoneuron firing in the lower limb typically increases after a remote handgrip contraction, believed to result from diffuse serotonergic input increases in spinal cord. We investigated whether handgrip contraction intensity, duration and/or impulse would affect PIC estimates in tibialis
Ugliara L +3 more
europepmc +2 more sources
Reversible cerebral vasoconstriction syndrome: A narrative review. [PDF]
Abstract Objectives/Background This review summarizes current insights into Reversible cerebral vasoconstriction syndrome (RCVS) diagnosis, management, and outcomes. RCVS is a cerebrovascular disorder characterized by recurrent thunderclap headaches and transient segmental vasoconstriction of cerebral arteries, typically resolving within 3 months ...
de Sousa ÍA +7 more
europepmc +2 more sources
Increases in cardiac vagal modulation following muscle mechanoreflex activation via passive calf stretch: Impact of interindividual differences. [PDF]
Abstract Muscle mechanoreflex is crucial to cardiac vagal modulation during exercise and can be activated during passive calf stretch. Herein, we aimed to determine whether cardiac vagal modulation following a single session of passive stretch is linked to interindividual cardiac vagal responses at the onset of passive calf muscle stretching in healthy
Lehnen GCS +6 more
europepmc +2 more sources
Can a Top Predator Persist After One of the World's Largest Mining Dam Failures? Occupancy Dynamics of the Neotropical Otter in Brazil's Paraopeba River. [PDF]
We evaluated the effects of the 2019 Brumadinho tailings‐dam collapse on neotropical otters (Lontra longicaudis) in Brazil's Paraopeba river using multi‐season occupancy models. Six years post‐collapse, otters showed high occupancy across impacted reaches.
Massara RL +10 more
europepmc +2 more sources
New insights into Ituglanis (Siluriformes: Trichomycteridae) diversity in Bahia State, eastern Brazil: Description of a new species and conservation status reappraisal. [PDF]
Abstract The northeastern Atlantic Forest of Brazil harbours a remarkable diversity of species of Trichomycteridae, many of which remain poorly understood. This study describes a new species of Ituglanis, endemic to the Ribeirão São Roque, a stream tributary of Rio Piabanha, an affluent of Rio Colônia basin, Bahia State, Brazil.
Vilardo PJ, Katz AM, Costa WJEM.
europepmc +2 more sources
Neural and Mechanical Adaptations During Static Stretching With Different Amplitudes. [PDF]
Prolonged static stretching elicits biphasic modulation of spinal excitability characterized by initial suppression followed by progressive facilitation that is amplitude‐dependent, with supramaximal stretching producing greater neural adaptations in both soleus and gastrocnemius muscles.
Vieira DCL +4 more
europepmc +2 more sources
ENTREVISTA COM O PROF. DR. ANTONIO TRAJANO MENEZES ARRUADA
Antonio Trajano Menezes Arruda (Trajano) graduou-se em Filosofia pela USP em 1969, concluiu o Mestrado em 1978 pela mesma instituição e obteve o Doutorado na University of Oxford/UK em 1985.
João Antonio de Moraes +1 more
doaj +1 more source
Los Domitii de Consabura y una noticia de Frontino
Este trabajo es una breve reflexión sobre algunas de las noticias de las fuentes clásicas acerca de la ciudad romana de Consabura (Consuegra, Toledo), y especialmente sobre las palabras de Frontino a propósito de la actuación del municipio durante la ...
María Pilar González-Conde Puente
doaj +1 more source

