Results 111 to 120 of about 1,061,883 (288)

Troponin T and Neurofilament Light Chain Levels as Complementary Biomarkers of Disease Accumulation and Aggressiveness in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin, Sofia Waldorf, Janina von der Gablentz, Torsten Grehl, Huelya Nazlican, Thomas Meyer, Julian Grosskreutz, Patrick Weydt, Sarah Bernsen   +8 more
wiley   +1 more source

A novel fuzzy system-based genetic algorithm for trajectory segment generation in urban global positioning system

Journal of Advanced Research
Introduction: The widespread adoption of Global Positioning System (GPS) technology has rendered trajectory data pivotal for urban traffic planning and travel pattern analysis.
Xiaojuan Ran, Naret Suyaroj, Worawit Tepsan, Mu Lei, Hongjiang Ma, Xiangbing Zhou, Wu Deng   +6 more
doaj   +1 more source

Trajectory Clustering by Sampling and Density

, 2014
The trajectory data of moving objects contain huge amounts of information pertaining to traffic flow. It is incredibly important to extract valuable knowledge from this particular kind of data.
Pan, Jiacai, Shao, Zheping, Jiang, Qings, 姜青山   +3 more
core  

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella, Veria Vacchiano, Vittorio Velucci, Stefano Zoccolella, Rocco Liguori, Giovanni Defazio   +5 more
wiley   +1 more source

Association Between Neurofilament Light Chain and Real‐World Ambulatory Function in Progressive MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurofilament light chain (NfL) is a biomarker of neuroaxonal injury in multiple sclerosis (MS), yet associations with functional outcomes remain unclear. Longitudinal associations between serum NfL (sNfL) and daily step count (STEPS) from wearable devices were assessed in a large international progressive MS cohort.
Gabby B. Joseph, Megan McCune, Riley Bove, Ahmed Abdelhak, Bruce A. C. Cree, Valerie J. Block   +5 more
wiley   +1 more source

A Qualitative Evaluation of Distance Measures in Trajectory Data Clustering

Trajectory clustering is one of the most important data mining tasks on this spatio-temporal data type. Many existing algorithms perform clustering by employing a distance measure designed specifically for trajectory data.
Grossniklaus, Michael, Bornholdt, Johann, Galetskiy, Max, Chondrogiannis, Theodoros   +3 more
core   +1 more source

Temporal Divergence of True and False Alarms in Pediatric Nocturnal Seizure Monitoring

Annals of Clinical and Translational Neurology, EarlyView.
The early‐morning surge in false seizure alarms supports exploring time‐ or state‐dependent detection thresholds to reduce false detections. ABSTRACT Seizure detection devices can improve the safety of children with epilepsy, yet high false alarms limit their clinical applicability.
Mohammad Shahbakhti, Anemoon T. Bosch, Job van der Palen, Franciscus S. Leijten, Johannes P. van Dijk, Richard H. C. Lazeron, Roland D. Thijs   +6 more
wiley   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Identifying and predicting Parkinson's disease subtypes through trajectory clustering via bipartite networks. [PDF]

PLoS One, 2020
Krishnagopal S, Coelln RV, Shulman LM, Girvan M.   +3 more
europepmc   +1 more source

Quantifying the clusterness and trajectoriness of single-cell RNA-seq data.

PLoS Computational Biology
Among existing computational algorithms for single-cell RNA-seq analysis, clustering and trajectory inference are two major types of analysis that are routinely applied.
Hong Seo Lim, Peng Qiu
doaj   +1 more source