Results 221 to 230 of about 1,061,883 (288)

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Checkpoint-enriched T cells with retained effector-associated features are associated with disease activity in systemic lupus erythematosus. [PDF]

Front Immunol
Santana-Sánchez P, Gajón JA, Ramírez-Pérez AA, Legorreta-Haquet MV, Amezcua-Guerra LM, Bonifaz LC, Chávez-Rueda AK.   +6 more
europepmc   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Spatiotemporally resolved single-nucleus transcriptomics reveals cellular and regional vulnerability in the midbrain in Parkinson's disease. [PDF]

Signal Transduct Target Ther
Yoo S, Lee K, Seo J, Choi H, Kim SI, Chang J, Shim YM, Kim J, Won JK, Park SH.   +9 more
europepmc   +1 more source

Longitudinal Morphomolecular Monitoring of Head and Neck Carcinogenesis

Advanced Science, EarlyView.
A miniaturized endoscopic probe that integrates Raman spectroscopy and optical coherence tomography, enabling simultaneous molecular and structural imaging of living tissue, was developed. Applied longitudinally in a mouse model of head and neck cancer, the system tracks disease progression from precancerous lesions to invasive cancer.
Jianrong Qiu, Priyanka G. Bhosale, Vishal Kumar, Jeyrroy Gabriel, Shiyue Liu, Ciro Chiappini, Richard J. Cook, Mads S. Bergholt   +7 more
wiley   +1 more source

Context-dependent protein structure prediction analysis and complex stoichiometry inference with MultimerMapper. [PDF]

Front Bioinform
Rodríguez Araya E, Serra E.
europepmc   +1 more source

Single-cell analysis of COPD: Microenvironmental interactions driven by immune-fibrotic imbalance. [PDF]

PLoS One
Jiang H, Wang W, Wang L, Wu J, Luo J, Yan Q, Gong X, Liang J.   +7 more
europepmc   +1 more source

Pathway representation <i>via</i> intrinsic structural medoids (PRISM): a structural mapping approach to clustering molecular pathways.

Digit Discov
Woody Santos JB, Leung JMG, Chong LT, Miranda-Quintana RA.   +3 more
europepmc   +1 more source