Results 231 to 240 of about 76,600 (295)

FastMDAnalysis: Software for Automated Analysis of Molecular Dynamics Trajectories. [PDF]

J Comput Chem
Aina A, Kwan D.
europepmc   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

A multi-layer regulatory landscape of chilling requirement revealed by stage-resolved transcriptomics and hormone profiling in peach floral buds. [PDF]

Front Plant Sci
Zhang W, Li H, Sun Y, Han Y, Wan B, Liao L.   +5 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Bio-Inspired Energy-Efficient Routing for Wireless Sensor Networks Based on Honeybee Foraging Behavior and MDP-Driven Adaptive Scheduling. [PDF]

Biomimetics (Basel)
Chen F, Wu X, Qi W, Wang Z, Wang Z, Li P.   +5 more
europepmc   +1 more source

Icariin Enhances the Enzymatic Activity of N‐acetylgalactosaminidase to Augment Akkermansia Abundance in Gut Microbiota for Improved PD‐1 Blockade Efficacy in Tumor Suppression

Advanced Science, EarlyView.
Icariin promoted the growth of Akk by enhancing the activity of N‐acetylgalactosaminidase (Amuc_0920), which enhanced mucin utilization and provided a favorable nutrient environment for bacterial growth. This icariin‐mediated enrichment of Akk further reshaped the tumor microenvironment and promoted CD8+ T cell infiltration, ultimately synergizing with
Shuangying Qiao, Liu Yang, Haibang Hao, Qiuxia Ding, Feng Ding, Zheng Chen, Jinfang Zhang, Yun He, Meng Li, Jun Xu, Chao Wang, Aiping Lu, Fangfei Li   +12 more
wiley   +1 more source

Trajectory Landscapes for Therapeutic Strategy Design in Agent-Based Tumor Microenvironment Models. [PDF]

IEEE Control Syst Lett
Cramer E, Heiser LM, Chang YH.
europepmc   +1 more source

Electrolyte trajectory-based subphenotypes and their association with hospital length of stay in prostate cancer patients. [PDF]

Transl Androl Urol
Shen Y, Xuan H, Wang J, Hu Y, Zhang Y.
europepmc   +1 more source

Single-cell RNA sequencing reveals immune microenvironment heterogeneity in BRCA1-mutated and sporadic triple-negative breast cancer. [PDF]

Transl Oncol
Sun Q, Zhong Y, Sun C.
europepmc   +1 more source

Multidimensional Recovery Trajectories Following Physiotherapy with or Without Pain Education in People with Chronic Low Back Pain. [PDF]

J Clin Med
Alalawi A.
europepmc   +1 more source