Results 121 to 130 of about 50,329,501 (342)

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

open access: yesFEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

A Microscopic On-Ramp Model Based on Macroscopic Network Flows

open access: yesApplied Sciences
While macroscopic traffic flow models adopt a fluid dynamic description of traffic, microscopic traffic flow models describe the dynamics of individual vehicles.
Niklas Kolbe   +4 more
doaj   +1 more source

Rapid Driving Style Recognition in Car-Following Using Machine Learning and Vehicle Trajectory Data

open access: yesJournal of Advanced Transportation, 2019
Rear-end collision crash is one of the most common accidents on the road. Accurate driving style recognition considering rear-end collision risk is crucial to design useful driver assistance systems and vehicle control systems.
Qing-Wen Xue, Ke Wang, J. Lu, Yu-Jie Liu
semanticscholar   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Trajectory generation for road vehicle obstacle avoidance using convex optimization [PDF]

open access: yes, 2010
This paper presents a method for trajectory generation using convex optimization to find a feasible, obstacle-free path for a road vehicle. Consideration of vehicle rotation is shown to be necessary if the trajectory is to avoid obstacles specified in a ...
H Gollee   +6 more
core   +1 more source

A Novel Approach for Online Car-Hailing Monitoring Using Spatiotemporal Big Data

open access: yesIEEE Access, 2019
Car-hailing service has increasingly become popular and fundamentally changed the way people travel in the era of sharing economy. Although such service brings convenience to people's lives, it also causes safety and property concerns.
Tong Zhou   +5 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Processed Trajectory Data

open access: yes
Processed data contains location, velocity, and time information on each particle trajectory as well as which trajectories intersect in such a way that scattering is ...
Griffin, Graeson
core   +1 more source

MGA trajectory planning with an ACO-inspired algorithm [PDF]

open access: yes, 2009
Given a set of celestial bodies, the problem of finding an optimal sequence of gravity assist manoeuvres, deep space manoeuvres (DSM) and transfer arcs connecting two or more bodies in the set is combinatorial in nature.
Vasile, M.   +3 more
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

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