Results 41 to 50 of about 51,257 (257)
Aerospace, 2023 The ability to accurately predict flight time of arrival in real time during a flight is critical to the efficiency and reliability of aviation system operations.
Zhe Zheng, Bo Zou, Wenbin Wei, Wen Tian
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Video-Based Reconstruction of the Trajectories Performed by Skiers
CoRR, 2021 Trajectories are fundamental in different skiing disciplines. Tools enabling the analysis of such curves can enhance the training activity and enrich the broadcasting contents. However, the solutions currently available are based on geo-localized sensors and surface models.
Matteo Dunnhofer +3 more
openaire +2 more sources
IEEE Access, 2019 In detection-based multi-object tracking (MOT), one challenging problem is to design a robust affinity model for data association. Moreover, since these approaches entirely rely on detection responses to locate targets, a strategy should be taken to deal
Jun Xiang, Guoshuai Zhang, Jianhua Hou
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Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Seven-dimensional trajectory reconstruction for VAMOS++
Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated EquipmentAccepted for publication in Nucl. Instr.
M. Rejmund, A. Lemasson
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IET Intelligent Transport SystemsTraditional methods of vehicle trajectory reconstruction heavily rely on the data of cross‐sectional traffic detectors, but the effectiveness of existing methods is limited by insufficient information of the cross‐sectional data.
Li Li +4 more
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source