Results 11 to 20 of about 10,443 (221)

Neutrophil-reactive autoantibodies in blood donors: Can we expect TRALI? [PDF]

Transfusion
Abstract Background Transfusion‐related acute lung injury (TRALI) is a clinical condition characterized by acute non‐cardiogenic pulmonary edema during or after transfusion. Despite several mitigation strategies, TRALI remains a leading cause of transfusion‐related deaths.
Jehle S, Preuss D, Waxmann Y, Spies-Naumann A, Schmidt S, Kapur R, Sachs UJ, Bayat B.   +7 more
europepmc   +2 more sources

Novel method for trend change detection and hypothesis generation in hemovigilance: A transfusion-related immunomodulation and blood production changes study. [PDF]

Transfusion
Abstract Background Immunomodulatory consequences of transfusion, known as transfusion‐related immune modulation (TRIM), impact patients but are not captured by hemovigilance systems. This study's objective is to explore TRIM impacts of production changes made by the blood supplier. Methods We included all transfused and non‐transfused adult inpatients
Ning S, Li N, Liu Y, Kim D, Acker JP, Arnold D, Hadzi-Tosev M, Hillis C, Kauffman A, Lucier KJ, Liaw PC, Rochwerg B, Syed S, Travis G, Zeller M, Heddle NM.   +15 more
europepmc   +2 more sources

Adverse events associated with use of immunoglobulin in pediatric patients reported to the US Food and Drug Administration Adverse Event Reporting System, 2001-2023. [PDF]

Pediatr Allergy Immunol
Abstract Background Immunoglobulin products are widely used for the treatment of immunodeficiency and autoimmune disorders. Although clinical trials have demonstrated their efficacy and tolerability, data describing their postmarketing safety profile in pediatric populations remain limited, particularly regarding rare and serious adverse events.
Wei S, Kim Y, Rubin MN, Ayyala SS, Welsh K.   +4 more
europepmc   +2 more sources

Tirofiban interferes with antibody-mediated transfusion-related acute lung injury by inhibiting platelet-neutrophil binding

Zhongguo shuxue zazhi, 2022
Objective To explore the feasibility of tirofiban, a platelet surface glycoprotein (GP)Ⅱb/Ⅲa receptor antagonist intervene in transfusion-related acute lung injury (TRALI), by inhibiting platelet activation and by preventing platelet and neutrophil ...
Xin YUAN, Yunhong YU, Congchao QIAO, Pan SUN, Na SU, Peng JIANG, Fangzhao LIN   +6 more
doaj   +1 more source

Pulmonary disease as a risk factor for transfusion-related acute lung injury

ERJ Open Research, 2021
Transfusion-related acute lung injury (TRALI) is a severe condition characterised by noncardiogenic pulmonary oedema that develops within 6 h of blood transfusion.
Akira Yokoyama, Yukiyo Sakamoto, Taisuke Jo, Hirokazu Urushiyama, Hiroyuki Tamiya, Goh Tanaka, Hiroki Matsui, Kiyohide Fushimi, Hideo Yasunaga, Takahide Nagase   +9 more
doaj   +1 more source

Study on the protective effect of rapamycin-treated dendritic cells on transfusion-related acute lung injury after infection

Zhongguo shuxue zazhi, 2022
Objective To investigate the viability of rapamycin-treated rapamycin-treated dendritic cells (DCs) in intervening transfusion-related acute lung injury (TRALI) after infection.
Li GAO, Yiming YANG, Rufeng XIE, Yuchun GONG, Juan SUN, Xueyu JIANG, Jie YANG   +6 more
doaj   +1 more source

Mechanism and intervention of murine transfusion-related acute lung injury caused by anti-CD36 antibodies

JCI Insight, 2023
Anti-CD36 Abs have been suggested to induce transfusion-related acute lung injury (TRALI) upon blood transfusion, particularly in Asian populations. However, little is known about the pathological mechanism of anti-CD36 Ab–mediated TRALI, and potential ...
Da-Wei Chen, Tian Kang, Xiu-Zhang Xu, Wen-Jie Xia, Xin Ye, Yong-Bin Wu, Yao-Ri Xu, Jing Liu, Hui Ren, Jing Deng, Yang-Kai Chen, Hao-Qiang Ding, Muhammad Aslam, Wioleta M. Zelek, B. Paul Morgan, Rick Kapur, Sentot Santoso, Yong-Shui Fu   +17 more
doaj   +1 more source

Blood product transfusion in emergency department patients: A case-control study of practice patterns and impact on outcome [PDF]

, 2017
Definitions of comorbid conditions.
Beyer, Alexander, Fuller, Brian M, Palmer, Christopher, Rees, Ryan, Wessman, Brian T   +4 more
core   +5 more sources

Severe antibody‐mediated transfusion‐related acute lung injury in an obstetric patient following transfusion of fresh frozen plasma from a non‐transfused male blood donor

Clinical Case Reports, 2021
Transfusion‐Related Acute Lung Injury (TRALI) has been associated with neutrophil reacting antibodies in transfused blood products. We report a case of life‐threatening TRALI in an obstetric patient triggered by transfusion from a non‐transfused male ...
Charlotte Nielsen Agergaard, Thure Mors Haunstrup, Anne‐Louise Fjordside, John Baech, Rudi Steffensen, Kaspar René Nielsen   +5 more
doaj   +1 more source

Leucoreduction of blood components. an effective way to increase blood safety? [PDF]

, 2015
Over the past 30 years, it has been demonstrated that removal of white blood cells from blood components is effective in preventing some adverse reactions such as febrile non-haemolytic transfusion reactions, immunisation against human leucocyte antigens
Bianchi, Maria, Facco, Giuseppina, Grazzini, Giuliano, Liumbruno, Giancarlo M, Marano, Giuseppe, Pupella, Simonetta, VAGLIO, Stefania   +6 more
core   +1 more source