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Drugs, 2003
The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.
Karen, McClellan, Lesley J, Scott
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The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.
Karen, McClellan, Lesley J, Scott
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The Pharmacogenetics of Tramadol
Clinical Pharmacokinetics, 2015Tramadol hydrochloride is used worldwide as an analgesic drug with a unique dual function. The metabolic enzymes cytochrome P450 (CYP) 3A4, CYP2B6, and CYP2D6 and the various transporters [adenosine triphosphate-binding cassette B1/multidrug resistance 1/P-glycoprotein, organic cation transporter 1, serotonin transporter (SERT), norepinephrine ...
Dorte Lassen, Per Damkier, Kim Brøsen
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Cochrane Database of Systematic Reviews, 2005
Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of ...
M S, Cepeda +3 more
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Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of ...
M S, Cepeda +3 more
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Current Opinion in Anaesthesiology, 2000
Tramadol is a unique analgesic offering moderate, dose-related pain relief through its action at multiple sites. In contrast to pure opioid agonists, it has a low risk of respiratory depression, tolerance and dependence. Troublesome side-effects have been reported, but tramadol has been established as an adjunct to non-steroidal anti-inflammatory drugs
P J, le Roux, J F, Coetzee
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Tramadol is a unique analgesic offering moderate, dose-related pain relief through its action at multiple sites. In contrast to pure opioid agonists, it has a low risk of respiratory depression, tolerance and dependence. Troublesome side-effects have been reported, but tramadol has been established as an adjunct to non-steroidal anti-inflammatory drugs
P J, le Roux, J F, Coetzee
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2013
A profile of the analgesic tramadol hydrochloride ((1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride) is provided in this chapter and includes a summary of the physical characteristics known for this drug substance (e.g., UV/vis, IR, NMR, and mass spectra). Details regarding the stability of tramadol hydrochloride in the
Robert, Smyj +2 more
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A profile of the analgesic tramadol hydrochloride ((1RS,2RS)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride) is provided in this chapter and includes a summary of the physical characteristics known for this drug substance (e.g., UV/vis, IR, NMR, and mass spectra). Details regarding the stability of tramadol hydrochloride in the
Robert, Smyj +2 more
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Douleur et Analgésie, 1997
Lors d'une etude randomisee effectuee en double aveugle, 35 patientes de classe ASA I et II recoivent une dose de charge de 150 mg de tramadol par voie intraveineuse, suivie dans le premier groupe d'une infusion de tramadol a 15 mg/heure ou dans le deuxieme groupe d'une perfusion de solution saline.
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Lors d'une etude randomisee effectuee en double aveugle, 35 patientes de classe ASA I et II recoivent une dose de charge de 150 mg de tramadol par voie intraveineuse, suivie dans le premier groupe d'une infusion de tramadol a 15 mg/heure ou dans le deuxieme groupe d'une perfusion de solution saline.
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Profile of Tramadol and Tramadol Analogues
2003Elmar Friderichs, Robert Raffa
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