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The Pharmacogenetics of Tramadol
Clinical Pharmacokinetics, 2015Tramadol hydrochloride is used worldwide as an analgesic drug with a unique dual function. The metabolic enzymes cytochrome P450 (CYP) 3A4, CYP2B6, and CYP2D6 and the various transporters [adenosine triphosphate-binding cassette B1/multidrug resistance 1/P-glycoprotein, organic cation transporter 1, serotonin transporter (SERT), norepinephrine ...
Kim Brøsen +4 more
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Cochrane Database of Systematic Reviews, 2005
Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of ...
Francisco Camargo +3 more
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Tramadol is increasingly used for the treatment of osteoarthritis because, in contrast to nonsteroidal anti-inflammatory drugs (NSAIDs), tramadol does not produce gastrointestinal bleeding or renal problems, and does not affect articular cartilage.We sought to determine the analgesic effectiveness, the effect on physical function, the duration of ...
Francisco Camargo +3 more
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Tramadol use and public health consequences in Iran: a systematic review and meta-analysis.
Addiction, 2020BACKGROUND AND AIMS Misuse of tramadol, an opioid prescription analgesic, is known as a public health challenge globally. We aimed to systematically review studies on the prevalence of non-prescribed use, regular tramadol use and dependence, tramadol ...
Yasna Rostam-Abadi +7 more
semanticscholar +1 more source
Drugs, 2003
The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.
Lesley J. Scott, Karen J. McClellan
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The orally administered fixed combination tablet of tramadol (centrally-acting opiate) plus paracetamol (acetaminophen; nonopiate, nonsalicylate analgesic) [37.5/325 mg] provides effective analgesia in patients with moderate to severe acute pain and those with chronic painful conditions characterised by intermittent exacerbations of pain.
Lesley J. Scott, Karen J. McClellan
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ADME and toxicity considerations for tramadol: from basic research to clinical implications
Expert Opinion on Drug Metabolism & Toxicology, 2020Introduction Tramadol is widely being used in chronic pain management for improving patients’ life quality and reducing trauma. Although it is listed in several medicinal guidelines, its use is controversial because of the conflicting results obtained in
Mohsen Doostmohammadi, H. Rahimi
semanticscholar +1 more source
Current Opinion in Anaesthesiology, 2000
Tramadol is a unique analgesic offering moderate, dose-related pain relief through its action at multiple sites. In contrast to pure opioid agonists, it has a low risk of respiratory depression, tolerance and dependence. Troublesome side-effects have been reported, but tramadol has been established as an adjunct to non-steroidal anti-inflammatory drugs
P J, le Roux, J F, Coetzee
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Tramadol is a unique analgesic offering moderate, dose-related pain relief through its action at multiple sites. In contrast to pure opioid agonists, it has a low risk of respiratory depression, tolerance and dependence. Troublesome side-effects have been reported, but tramadol has been established as an adjunct to non-steroidal anti-inflammatory drugs
P J, le Roux, J F, Coetzee
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Microscopy and Microanalysis, 2020
Tramadol is a centrally acting analgesic drug, used for the management of moderate to severe pain in a variety of diseases. The long-term use of tramadol can induce endocrinopathy.
A. Shalaby +3 more
semanticscholar +1 more source
Tramadol is a centrally acting analgesic drug, used for the management of moderate to severe pain in a variety of diseases. The long-term use of tramadol can induce endocrinopathy.
A. Shalaby +3 more
semanticscholar +1 more source
Biomimetic synthesis of Tramadol
Chemical Communications, 2015The key step in the proposed biosynthesis of tramadol was achieved using mild biomimetic conditions.
Soura Challal +17 more
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Douleur et Analgésie, 1997
Lors d'une etude randomisee effectuee en double aveugle, 35 patientes de classe ASA I et II recoivent une dose de charge de 150 mg de tramadol par voie intraveineuse, suivie dans le premier groupe d'une infusion de tramadol a 15 mg/heure ou dans le deuxieme groupe d'une perfusion de solution saline.
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Lors d'une etude randomisee effectuee en double aveugle, 35 patientes de classe ASA I et II recoivent une dose de charge de 150 mg de tramadol par voie intraveineuse, suivie dans le premier groupe d'une infusion de tramadol a 15 mg/heure ou dans le deuxieme groupe d'une perfusion de solution saline.
openaire +2 more sources