Results 71 to 80 of about 3,521 (321)

Appendix 3: Sources for Agents Used in Sedating, Tranquilizing, Immobilizing, and Anesthetizing Elephants [PDF]

, 2006

openalex   +1 more source

Concentration and Detection Time of Nitrous Oxide in Blood Following Controlled Inhalation

Drug Testing and Analysis, EarlyView.
In a study with controlled inhalation of nitrous oxide (N2O), elimination followed a two‐compartment model with half‐lives of 2.4 and 31 min, and N2O remained detectable in blood samples for 1–3 h after inhalation. ABSTRACT Recreational use of nitrous oxide (laughing gas, N2O) is becoming increasingly common and abuse is often seen in relation to ...
Angelica Ørregaard Lindholm, Marie Katrine Klose Nielsen, Mette Kristensen, Mo Haslund Larsen, Johan Heiberg, Brian Schou Rasmussen   +5 more
wiley   +1 more source

From Biological to Synthetic Neurorobotics Approaches to Understanding the Structure Essential to Consciousness (Part 3) [PDF]

, 2016
This third paper locates the synthetic neurorobotics research reviewed in the second paper in terms of themes introduced in the first paper. It begins with biological non-reductionism as understood by Searle.
Tani, Jun, White, Jeff
core   +2 more sources

Continuous outcome estimation in N‐of‐1 trials for accelerated decision‐making

Epilepsia, EarlyView.
Abstract Objective N‐of‐1 trials aim to determine the therapeutic effect for a single individual. This individualized approach necessitates collecting multiple data points over time through repeated alternating periods of active treatment and a comparator or control condition.
Victoria Defelippe, František Bartoš, Eric‐Jan Wagenmakers, Kees P. J. Braun, Floor E. Jansen, Willem M. Otte   +5 more
wiley   +1 more source

Fast cycle of vagus nerve stimulation is associated with increased sleep‐related breathing disorder in patients with epilepsy

Epilepsia, EarlyView.
Abstract Objective This work was undertaken to study the association between vagus nerve stimulation (VNS) parameters and the apnea–hypopnea index (AHI) measured by polysomnography in patients with drug‐resistant epilepsy. Methods Patients with epilepsy who underwent polysomnography with an active VNS device between 2018 and 2023 were retrospectively ...
Jacques‐François Massa, Nada El Youssef, Romain Carron, Pauline Garcia, Agnès Trebuchon, Bernard Giusiano, Fabrice Bartolomei, Angela Marchi, Isabelle Lambert   +8 more
wiley   +1 more source

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

Women with epilepsy: Evidence‐based counseling across the lifespan

Epilepsia, EarlyView.
Abstract Women with epilepsy (WWE) encounter distinct and evolving challenges across the lifespan that require clinical management extending beyond seizure control alone. Although awareness of sex‐specific aspects of epilepsy has increased, important gaps remain in their integration into routine care.
Barbara Tettenborn, Georgia Ramantani, Dominique Flügel, Verena Gaus, Susanne Schubert‐Bast, Elisabeth Sellitto, Jennifer Bausch, Bettina Schmitz   +7 more
wiley   +1 more source

The multiple hit model of infantile and epileptic spasms: The 2025 update

Epilepsia Open, EarlyView.
Abstract Objective Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.
Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé   +6 more
wiley   +1 more source

Characterizing electroencephalogram dynamics during sedation withdrawal: Insights into cortical recovery following status epilepticus

Epilepsia Open, EarlyView.
Abstract Objective Characterize electroencephalogram (EEG) dynamics during propofol withdrawal in patients with generalized convulsive status epilepticus (GCSE) and explore their association with functional outcomes. Methods We conducted a retrospective cohort study of adult patients with GCSE who received continuous EEG monitoring and propofol ...
Mathieu Dhoisne, Philippe Derambure, Arnaud Delval, Saad Nseir, Nacim Betrouni, Romain Tortuyaux   +5 more
wiley   +1 more source

Practical consensus recommendations for polytherapy involving stiripentol in Dravet syndrome: A nominal group approach

Epilepsia Open, EarlyView.
Abstract Objectives Dravet syndrome (DS) is a drug‐resistant developmental and epileptic encephalopathy, often requiring three or more antiseizure medications (ASMs). Consequently, the therapeutic landscape is highly complex, combining DS‐specific agents (stiripentol, STP; cannabidiol, CBD; fenfluramine, FFA), non‐specific ASMs, and non‐pharmacologic ...
J. Helen Cross, Rima Nabbout, Barry Gidal, Joseph Sullivan, Elaine Wirrell   +4 more
wiley   +1 more source