Results 111 to 120 of about 59,578 (250)

DRB4 dsRBD1 drives dsRNA recognition in Arabidopsis thaliana tasi/siRNA pathway

Nucleic Acids Research, 2017
In Arabidopsis thaliana, endogenous trans-acting and exogenous siRNA pathways are initiated by the interaction of DRB4 with trigger dsRNA. Further, DCL4:DRB4 complex cleaves the dsRNA into 21 bp siRNA. Understanding molecular determinants and mechanistic
S. Chiliveri, R. Aute, Upasana Rai, M. Deshmukh   +3 more
semanticscholar   +1 more source

Supramolecular Assembly of Triterpenoids: Current State and Biomedical Perspectives

Aggregate, EarlyView.
Triterpenoids serve as both exceptional molecular motifs for supramolecular assembly and versatile therapeutic agents, offering broad biological functions to improve health outcomes and enhance treatment efficacy. This review comprehensively summarizes recent advances in triterpenoid‐based supramolecular systems, including their roles as functional ...
Jie Zhong, Juan C. Mareque‐Rivas, Xinmiao Lan, Yu‐Xiong Su   +3 more
wiley   +1 more source

Extramitochondrial OPA1 and adrenocortical function [PDF]

, 2013
We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial 27 Ca2+ signaling and aldosterone production in H295R adrenocortical cells.
András Spät, Anikó Rajki, Arnoult, Balla, Belenguer, Bell, Betancourt-Calle, Brasaemle, Cherradi, Cherradi, Cipolat, Clark, Cortese, Coulombe, Delettre, Durroux, Dyson, Dávid Katona, Enyedi, Enyedi, Eura, Fleury, Frey, Fülöp, Gallo-Payet, Gergö Szanda, Granneman, Granneman, Greenberg, Greenberg, Gutowski, Hajnóczky, Hanoune, Hattangady, Hausdorff, Hirsch, Holm, Holysz, Hsieh, Hunyady, Joiner, Kraemer, Kramer, Kushnareva, Lenaers, Lenglet, Liesa, Lucki, László Fülöp, Mallilankaraman, Manna, Martin, Maturana, Midzak, Miyoshi, Olichon, Pidoux, Pralong, Rizzuto, Rodrigueza, Rone, Satoh, Scorrano, Servetnick, Sperelakis, Spät, Spät, Subramanian, Sukhorukov, Sztalryd, Tait, Tansey, Tremblay, Trzeciak, Vinson, Wasilewski, Wiederkehr, Wong, Yamaguchi, Zhang, Zimmermann   +80 more
core   +1 more source

Conditional Stabilization of the Hypoxia‐Inducible Factor HIF1α — Photoswitchable Stapled Peptides Prevent Elongin BC Mediated Degradation

Angewandte Chemie International Edition, Accepted Article.
Oxygen levels and its distribution are tightly regulated due to their critical impact on health. Hypoxia‐inducible factors (HIFs) are traditionally recognized as key regulators of the transcriptional response to low oxygen (hypoxia). Recent research expanded their functions, highlighting their potential as therapeutic targets.
Van Tuan Trinh, Sabrina Fischer, Lei Zhang, Heiko Geisler, Belen Pardo, Robert Liefke, Frank Abendroth, Olalla Vazquez   +7 more
wiley   +1 more source

Specific Rab GTPase-activating proteins define the Shiga toxin and epidermal growth factor uptake pathways [PDF]

, 2007
Rab family guanosine triphosphatases (GTPases) together with their regulators define specific pathways of membrane traffic within eukaryotic cells. In this study, we have investigated which Rab GTPase-activating proteins (GAPs) can interfere with the ...
Barr, Francis A., Fuchs, Evelyn, Hass, Alexander K., Lord, Mike, Spooner, Robert A., Yoshimura, Shin-ichiro   +5 more
core   +2 more sources

A diverse and evolutionarily fluid set of microRNAs in Arabidopsis thaliana.

Genes & Development, 2006
To better understand the diversity of small silencing RNAs expressed in plants, we employed high-throughput pyrosequencing to obtain 887,000 reads corresponding to Arabidopsis thaliana small RNAs.
R. Rajagopalan, H. Vaucheret, Jerry Trejo, D. Bartel   +3 more
semanticscholar   +1 more source

Decoding regulatory programs underlying placode and dermal condensate cell fate commitment during hair follicle induction via single‐cell multi‐omics analysis

Animal Research and One Health, EarlyView.
The experimental framework of the study encompasses sample collection, single‐cell data analysis, and experimental validation. Abstract Understanding differences in chromatin state and changes in gene regulatory landscape of placode (Pc) and dermal condensate are crucial for decoding hair follicle (HF) morphogenesis programs.
Fang Li, Minghao Li, Tongtong Zhang, Menghua Sui, Hasan Khatib, Xin Wang   +5 more
wiley   +1 more source

tasiRNAdb: a database of ta-siRNA regulatory pathways

Bioinform., 2014
SUMMARY In plants, many trans-acting small interfering RNA (ta-siRNA) regulatory pathways have been identified as significant components of the gene networks involved in development, metabolism, responses to biotic and abiotic stresses and DNA ...
Changqing Zhang, Guangping Li, Shinong Zhu, Shuo Zhang, Jinggui Fang   +4 more
semanticscholar   +1 more source

Innovative transdermal drug delivery systems: Benefits, challenges, and emerging application

BMEMat, EarlyView.
The graphical abstract illustrates the diverse nanostructures employed in transdermal drug delivery systems, highlighting their unique mechanisms to penetrate the intricate layers of skin. It provides a detailed representation of the skin's complex anatomy, emphasizing the challenges posed by its barrier properties.
Syed Waqas Ali Shah, Xingxing Li, Hao Yuan, Huiling Shen, Shaohao Quan, Guifang Pan, Muhammad Ishfaq, Abid Ullah Shah, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source

Neutrophils in cancer: At the crucial crossroads of anti‐tumor and pro‐tumor

Cancer Communications, EarlyView.
Abstract Neutrophils are important components of the immune system and play a key role in defending against pathogenic infections and responding to inflammatory cues, including cancer. Their dysregulation indicates potential disease risk factors. However, their functional importance in disease progression has often been underestimated due to their ...
Wenpeng Cai, Tao Fan, Chu Xiao, Ziqin Deng, Yixiao Liu, Chunxiang Li, Jie He   +6 more
wiley   +1 more source