Results 1 to 10 of about 222,198 (258)

Updates in Small Interfering RNA for the Treatment of Dyslipidemias. [PDF]

Curr Atheroscler Rep, 2023
Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological approaches, clinical registries consistently show that many people with dyslipidemia do not achieve optimal management, and many of them are treated with low-intensity
Carugo S, Sirtori CR, Gelpi G, Corsini A, Tokgozoglu L, Ruscica M.   +5 more
europepmc   +3 more sources

Small interfering RNA; toward a new antiviral therapy [PDF]

Records of Pharmaceutical & Biomedical Sciences, 2022
With the ability of viruses to mutate and introduce a high rate of diversity and continuous resistance to drug development, unique solutions are needed. RNA interference (RNAi) pathway as a natural defense mechanism mediated by plants, invertebrates, and
Engy Aziza
doaj   +1 more source

Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview. [PDF]

Pharmaceutics
Introduction: Gene therapy using siRNA is a current area of research in oncology. Although siRNA formulations have not yet been approved for cancer therapy, numerous studies have demonstrated their therapeutic potential for tumor remission. Objective: To
Aranda-Lara L, Escudero-Castellanos A, Trujillo-Nolasco M, Morales-Avila E, Ocampo-García B, Oros-Pantoja R, Sánchez-Monroy V, Isaac-Olivé K.   +7 more
europepmc   +2 more sources

Effects of LINC00261 targeting miR-148a/WNT10b axis on the proliferation and apoptosis of colorectal cancer cells

Heliyon, 2023
Objective: Colorectal cancer remains a significant challenge with high mortality rates. The aim of this study was to investigate the effect of targeting the microRNA-148a/WNT10b axis with the long non-coding RNA LINC00261 on the proliferation and ...
Juanli Xi, Lei Shi, DingJie Zhou, Dedong Cao, Bo Peng   +4 more
doaj   +1 more source

Potential of siRNA in COVID-19 therapy: Emphasis on in silico design and nanoparticles based delivery

Frontiers in Bioengineering and Biotechnology, 2023
Small interfering RNA (siRNA)-mediated mRNA degradation approach have imparted its eminence against several difficult-to-treat genetic disorders and other allied diseases.
Rushikesh Fopase, Chinmaya Panda, Amarnath P. Rajendran, Hasan Uludag, Hasan Uludag, Hasan Uludag, Lalit M. Pandey   +6 more
doaj   +1 more source

Small interfering RNA effect on lipoprotein(a): a systematic review. [PDF]

Egypt Heart J
Background This systematic review investigates the effect of small interfering RNA (siRNA) therapies on lipoprotein(a) [Lp(a)] levels. The purpose is to evaluate the outcomes of recent randomized controlled trials (RCTs) involving siRNA treatments aimed ...
Almaadawy O, Hesn MM, Elsalamony YA, Abobakr OA, Elshimy AH, Abulkhair KA, Negm MM, Shaban AY, Bene-Alhasan Y, Annie F, Belcher A, Elashery AR.   +11 more
europepmc   +2 more sources

Small interfering RNA: From designing to therapeutic in cancer. [PDF]

J Genet Eng Biotechnol
Cancer has become a significant public health concern worldwide. It is a group of diseases, often resulting from the dysregulation of multiple cellular pathways involved in differentiation, cell proliferation, cell cycle regulation, and DNA repair. These
Singh J, Saeedan AS, Kaithwas G, Ansari MN.   +3 more
europepmc   +2 more sources

stepRNA: Identification of Dicer cleavage signatures and passenger strand lengths in small RNA sequences

Frontiers in Bioinformatics, 2022
The enzyme Dicer is a component of many small RNA (sRNA) pathways involved in RNA processing for post-transcriptional regulation, anti-viral response and control of transposable elements.
Ben Murcott, Rebecca J. Pawluk, Anna V. Protasio, Ruth Y. Akinmusola, Dominika Lastik, Vicky L. Hunt   +5 more
doaj   +1 more source

siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database. [PDF]

IET Syst Biol
Small interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology.
Zhang Y, Yang T, Yang Y, Xu D, Hu Y, Zhang S, Luo N, Ning L, Ren L.   +8 more
europepmc   +2 more sources

Small Interfering RNA- Modern Approach for Intervening Pathological Conditions

NUST Journal of Natural Sciences, 2021
RNA interference (RNAi) refers to the inhibition of gene expression by small double-stranded RNA molecules. This technology can prove to be a breakthrough biological discovery of the decade as it has the potential to revolutionize the field of ...
Shazia Choudhary, Sheeba Murad, Sana Gul, Hayat Khan, Samra Khalid, Summar Gul, Naureen Ehsan , Mamoona Noreen   +7 more
doaj   +1 more source