Results 21 to 30 of about 222,198 (258)

Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib

Haematologica, 2010
Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff, Lambros Kordelas, Dietrich W. Beelen, Ahmet H. Elmaagacli   +3 more
doaj   +1 more source

Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants. [PDF]

Pharmaceuticals (Basel)
RNA interference (RNAi) was originally regarded as a mechanism of eukaryotic post-transcriptional gene regulation mediated by small interfering RNA (siRNA)-induced sequence-specific RNA degradation.
Kang H, Ga YJ, Kim JW, Kim C, Son SH, Gwak C, Yeh JY.   +6 more
europepmc   +2 more sources

An endogenous small interfering RNA pathway in Drosophila [PDF]

Nature, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of approximately 22 nucleotides in length, which arise from structured precursors through the action of Drosha-Pasha and Dicer-1-Loquacious complexes.
Czech, Benjamin, Malone, Colin D., Zhou, Rui, Stark, Alexander, Schlingeheyde, Catherine, Dus, Monica, Perrimon, Norbert, Kellis, Manolis, Wohlschlegel, James A., Sachidanandam, Ravi, Hannon, Gregory J., Brennecke, Julius   +11 more
openaire   +4 more sources

Therapeutic potential of small interfering RNAs/micro interfering RNA in hepatocellular carcinoma [PDF]

World Journal of Gastroenterology, 2015
Hepatocellular carcinoma (HCC) is the predominant form of primary liver cancer and represents the third leading cause of cancer-related death worldwide. Current available therapeutic approaches are poorly effective, especially for the advanced forms of the disease.
FARRA, ROSSELLA, GRASSI, Mario, GRASSI, GABRIELE, DAPAS, BARBARA   +3 more
openaire   +3 more sources

Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production

Frontiers in Bioengineering and Biotechnology, 2020
RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse ...
Peike Sheng, Peike Sheng, Krystal A. Flood, Krystal A. Flood, Mingyi Xie, Mingyi Xie, Mingyi Xie   +6 more
doaj   +1 more source

Effect of silencing on proliferation and apoptosis of melanoma cells: An in vivo and in vitro study

Tumor Biology, 2017
This study aimed to investigate the effect of SOCS1 silencing on the proliferation and apoptosis of melanoma cells by in vivo and in vitro studies. Immunohistochemical staining was used to detect SOCS1 expression in melanoma tissues and pigmented nevi ...
Sheng-Jia Yu, Zi-Wen Long
doaj   +1 more source

The optimal concentration of siRNA for gene silencing in primary cultured astrocytes and microglial cells of rats [PDF]

Korean Journal of Anesthesiology, 2010
BackgroundSmall interfering RNAs (siRNAs) have been used to knockdown specific gene expression in various cells. Astrocytes and microglial cells play a key role in fundamental central nervous system functions and in chronic neuroinflammation. The aims of
Kyeong Ho Ki, Do Yang Park, Soo Han Lee, Nam Yun Kim, Byung Moon Choi, Gyu Jeong Noh   +5 more
doaj   +1 more source

Small Interfering RNA (siRNA) in Dyslipidemia: A Systematic Review on Safety and Efficacy of siRNA. [PDF]

J Exp Pharmacol
Sai Santhosha Mrudula Alla,1 Dhruv Jayeshkumar Shah,2 Shourya Meyur,3 Pahel Agarwal,4 Deekshitha Alla,1 Sai Lokesh Moraboina,5 Gayatri Vijay Ghadvaje,6 Ruth Getaneh Bayeh,7 Aparna Malireddi,1 Tess Shajan,8 Bodipudi Vineetha,5 Thalvayapati Sai Prudhvi,9 ...
Alla SSM, Shah DJ, Meyur S, Agarwal P, Alla D, Moraboina SL, Ghadvaje GV, Bayeh RG, Malireddi A, Shajan T, Vineetha B, Sai Prudhvi T, Biziyaremye P.   +12 more
europepmc   +2 more sources

New Insight into Inter-kingdom Communication: Horizontal Transfer of Mobile Small RNAs

Frontiers in Microbiology, 2017
Small RNAs (sRNAs), including small interfering RNAs (siRNAs) and microRNAs (miRNAs), are conventionally regarded as critical molecular regulators of various intracellular processes.
Xi Chen, Geyu Zhou, Yu Zhou
doaj   +1 more source

Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges

Journal of Biomedical Science, 2023
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles extending beyond its applications in vaccines, in which it is used in the response to the COVID-19 pandemic.
Hara Kang, Yun Ji Ga, Soo Hyun Kim, Young Hoon Cho, Jung Won Kim, Chaeyeon Kim, Jung-Yong Yeh   +6 more
doaj   +1 more source