Results 21 to 30 of about 348,107 (298)

Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future

CHIMIA, 2022
The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years.
Jonathan Hall, Anastasia Ashkinadze, Jan Philipp Becker, Artur Laski, Eva-Maria Manz, Štefan Moravčík, Sebastian Sjöström, Mathilde Vincent   +7 more
doaj   +1 more source

The antiviral RNAi response in vector and non-vector cells against orthobunya viruses [PDF]

, 2017
Background: Vector arthropods control arbovirus replication and spread through antiviral innate immune responses including RNA interference (RNAi) pathways. Arbovirus infections have been shown to induce the exogenous small interfering RNA (siRNA) and
Bausch, DG, Blomström, AL, Dietrich, I, Elliott, RM, Kohl, A, McFarlane, M, Schnettler, E, Shi, X, Skelton, JK, Watson, M   +9 more
core   +5 more sources

Small interfering RNA against BCR-ABL transcripts sensitize mutated T315I cells to nilotinib

Haematologica, 2010
Background Selective inhibition of the BCR-ABL tyrosine kinase by RNA interference has been demonstrated in leukemic cells. We, therefore, evaluated specific BCR-ABL small interfering RNA silencing in BCR-ABL-positive cell lines, including those ...
Michael Koldehoff, Lambros Kordelas, Dietrich W. Beelen, Ahmet H. Elmaagacli   +3 more
doaj   +1 more source

Transfer RNA-derived small RNAs in the cancer transcriptome [PDF]

, 2016
The cellular lifetime includes stages such as differentiation, proliferation, division, senescence and apoptosis.These stages are driven by a strictly ordered process of transcription dynamics.
A Dueck, A Sobala, AE Hall, AM Burroughs, C Cole, C Fricke, D Green, D Haussecker, D Kim, Darrell Green, DM Thompson, DP Bartel, DR Rhodes, FE Nicolas, GL Hager, H Fu, H Goodarzi, I Salaverria, JM Perkel, M Ghildiyal, M Talpaz, MS Pagter de, NC Schopman, O Rechavi, P Adjibade, P Ivanov, P Kumar, P Kumar, Q Wang, R Levitz, RL Maute, S Yamasaki, SC Stearns, T Uchiumi, Tamas Dalmay, U Harms, William D. Fraser, YS Lee, Z Li   +38 more
core   +1 more source

An endogenous small interfering RNA pathway in Drosophila [PDF]

, 2008
Drosophila endogenous small RNAs are categorized according to their mechanisms of biogenesis and the Argonaute protein to which they bind. MicroRNAs are a class of ubiquitously expressed RNAs of 22 nucleotides in length, which arise from structured ...
A Eulalio, A Stark, AA Aravin, Alexander Stark, AM Denli, Benjamin Czech, C Klattenhoff, Catherine Schlingeheyde, Colin D. Malone, D Galiana-Arnoux, E Allen, E Bernstein, E Yigit, F Jiang, Gregory J. Hannon, J Brennecke, J Jurka, J Pak, J Rehwinkel, James A. Wohlschlegel, JG Ruby, JG Ruby, Julius Brennecke, K Forstemann, K Forstemann, K Okamura, K Saito, K Saito, LS Gunawardane, Manolis Kellis, Monica Dus, N Bushati, Norbert Perrimon, Q Liu, Ravi Sachidanandam, Rui Zhou, T Sijen, VV Vagin, XH Wang, Y Lee, Y Tomari, YS Lee   +41 more
core   +1 more source

Polymers in Small-Interfering RNA Delivery [PDF]

Oligonucleotides, 2011
This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic- co -glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers ...
Singha, K, Namgung, R, Kim, WJ
openaire   +3 more sources

Inhibition of hepatitis C virus RNA replication by ISG15 does not require its conjugation to protein substrates by the HERC5 E3 ligase [PDF]

, 2015
Chronic infection of the liver by hepatitis C virus (HCV) induces a range of host factors including IFN-stimulated genes such as ISG15. ISG15 functions as an antiviral factor that limits virus replication. Previous studies have suggested that ISG15 could
Bamford, Connor G.G., Boutell, Chris, Domingues, Patricia, McLauchlan, John   +3 more
core   +2 more sources

Therapeutic opportunities of small interfering RNA [PDF]

Fundamental & Clinical Pharmacology, 2009
AbstractFormation of small interfering RNA (siRNA) occurs in two steps involving binding of the RNA nucleases to a large double‐stranded RNA (dsRNA) and its cleavage into fragments called siRNA. In the second step, these siRNAs join a multinuclease complex, which degrades the homologous single‐stranded mRNAs.
Bhoomika R, Goyal, Mayur M, Patel, Mithil K, Soni, Shraddha V, Bhadada   +3 more
openaire   +2 more sources

Short Hairpin RNAs for Strand-Specific Small Interfering RNA Production

Frontiers in Bioengineering and Biotechnology, 2020
RNA interference (RNAi) is an effective mechanism for inhibiting gene expression at the post-transcriptional level. Expression of a messenger RNA (mRNA) can be inhibited by a ∼22-nucleotide (nt) small interfering (si)RNA with the corresponding reverse ...
Peike Sheng, Peike Sheng, Krystal A. Flood, Krystal A. Flood, Mingyi Xie, Mingyi Xie, Mingyi Xie   +6 more
doaj   +1 more source

Gene silencing in tick cell lines using small interfering or long double-stranded RNA [PDF]

, 2012
Gene silencing by RNA interference (RNAi) is an important research tool in many areas of biology. To effectively harness the power of this technique in order to explore tick functional genomics and tick-microorganism interactions, optimised parameters ...
A-C Barnard, AA Latif, AE Lew-Tabor, Alain Kohl, AM Nijhof, AM Nijhof, CL Donald, DE Brackney, EF Blouin, EM Morazzani, Esther Schnettler, F Jongejan, G Attarzadeh-Yazdi, G Barry, Gerald Barry, GJ Hannon, I Sifuentes-Romero, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, J Fuente de la, JC Clemens, JC Scott, JE George, JH Pedra, John K. Fazakerley, K Kiiver, KM Kocan, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Bell-Sakyi, L Song, Lesley Bell-Sakyi, MGR Varma, P Liljestrom, P Lingor, P Willadsen, Pilar Alberdi, R Fragkoudis, R Fragkoudis, RA Zambon, S Bivalkar-Mehla, S Garcia, S Garcia, S Kurscheid, S Narasimhan, Sabine Weisheit, SM Hammond, SW Ding, TJ Kurtti, TJ Kurtti, UG Munderloh, V Nene, V Shkap, Z Zivkovic, Z Zivkovic   +57 more
core   +4 more sources