Results 31 to 40 of about 222,198 (258)
The specifics of small interfering RNA specificity [PDF]
Proceedings of the National Academy of Sciences, 2003 The discovery of transgene silencing in plants and double-stranded RNA (dsRNA) interference in the worm Caenorhabditis elegans has led to the latest revolution in molecular biology, RNA interference (RNAi). Over 10 years ago it was noted that several transgenic plant lines each containing the same ectopic transgene not only failed to be expressed but ...
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Delivery of therapeutic small interfering RNA: The current patent-based landscape
Molecular Therapy: Nucleic Acids, 2022 Implementing small interfering RNA (siRNA) is a promising therapy because it silences disease-related genes theoretically. However, the efficient delivery of siRNA is challenging, which limits its therapeutic applications. Various pharmaceutical delivery
Yu Chen +7 more
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Small interfering RNAs in the management of human osteoporosis
British Medical Bulletin, 2023 Abstract Background Osteoporosis results in reduced bone mass and consequent bone fragility. Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets or as useful markers to test new therapies. Sources of data
Giuseppe Gargano +4 more
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Tumor Biology, 2017 Although gene therapy has brought new insights into the treatment of malignant melanoma, targeting delivery of nucleic acid which targets critical oncogene/anti-oncogene in vivo is still a bottleneck in the therapeutic application.
Hao Wang +7 more
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Small Interfering RNA for Gliomas Treatment: Overcoming Hurdles in Delivery
Frontiers in Cell and Developmental Biology, 2022 Gliomas are central nervous system tumors originating from glial cells, whose incidence and mortality rise in coming years. The current treatment of gliomas is surgery combined with chemotherapy or radiotherapy. However, developing therapeutic resistance
Xin-Qi Teng +7 more
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Unzipping and binding of small interfering RNA with single walled carbon nanotube: A platform for small interfering RNA delivery [PDF]
The Journal of Chemical Physics, 2012 In an effort to design efficient platform for siRNA delivery, we combine all atom classical and quantum simulations to study the binding of small interfering RNA (siRNA) by pristine single wall carbon nanotube (SWCNT). Our results show that siRNA strongly binds to SWCNT surface via unzipping its base-pairs and the propensity of unzipping increases with
Santosh, Mogurampelly +4 more
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Characterization of the small RNA transcriptome of the diatom, Thalassiosira pseudonana. [PDF]
PLoS ONE, 2011 This study presents the first characterization of endogenous small RNAs in a diatom, Thalassiosira pseudonana. Small RNAs act as transcriptional and translational regulators, controlling specific target genes involved in various cellular functions ...
Trina M Norden-Krichmar +3 more
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Phenotypic Alteration of BMDM In Vitro Using Small Interfering RNA
Cells, 2022 Autologous macrophage transfer is an emerging platform for cell therapy. It is anticipated that conventional macrophage reprogramming based on ex vivo polarization using cytokines and ligands of TLRs may enhance the therapeutic effect.
Noreen Halimani +11 more
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Oligonucleotide Therapeutics: From Discovery and Development to Patentability
Pharmaceutics, 2022 Following the first proof of concept of using small nucleic acids to modulate gene expression, a long period of maturation led, at the end of the last century, to the first marketing authorization of an oligonucleotide-based therapy.
Lara Moumné +2 more
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Phased secondary small interfering RNAs in Panaxnotoginseng [PDF]
BMC Genomics, 2018 أظهرت النتائج الحديثة أن الجينات غير المشفرة أو الترميز تولد الحمض النووي الريبي الثانوي المتداخل الصغير المرحلي (phasiRNAs) الذي يسترشد بحمض نووي مرئي محدد. حتى الآن، لا توجد دراسات للحمض النووي الريبي الطوري في باناكس نوتوجينسينغ (بورك.) ف.ه. تشين (P. notoginseng)، وهو نوع مهم من النباتات الطبية العشبية الصينية التقليدية.
Kun Chen +11 more
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