Small interfering RNA (siRNA)-based targeting breast cancer therapy [PDF]
Discover OncologyBreast cancer (BC) poses a substantial impact on the global health landscape, thereby demanding the creation of novel therapeutic approaches aimed at enhancing patient outcomes.
Amin Talebi +8 more
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Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview [PDF]
PharmaceuticsIntroduction: Gene therapy using siRNA is a current area of research in oncology. Although siRNA formulations have not yet been approved for cancer therapy, numerous studies have demonstrated their therapeutic potential for tumor remission. Objective: To
Liliana Aranda-Lara +7 more
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Small interfering RNA: From designing to therapeutic in cancer [PDF]
Journal of Genetic Engineering and BiotechnologyCancer has become a significant public health concern worldwide. It is a group of diseases, often resulting from the dysregulation of multiple cellular pathways involved in differentiation, cell proliferation, cell cycle regulation, and DNA repair. These
Jyoti Singh +3 more
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Small interfering RNA effect on lipoprotein(a): a systematic review [PDF]
The Egyptian Heart JournalBackground This systematic review investigates the effect of small interfering RNA (siRNA) therapies on lipoprotein(a) [Lp(a)] levels. The purpose is to evaluate the outcomes of recent randomized controlled trials (RCTs) involving siRNA treatments aimed ...
Omar Almaadawy +11 more
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siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database [PDF]
IET Systems BiologySmall interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology.
Yang Zhang +8 more
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Polymers in Small-Interfering RNA Delivery [PDF]
Oligonucleotides, 2011 This review will cover the current strategies that are being adopted to efficiently deliver small interfering RNA using nonviral vectors, including the use of polymers such as polyethylenimine, poly(lactic- co -glycolic acid), polypeptides, chitosan, cyclodextrin, dendrimers, and polymers ...
Singha, K, Namgung, R, Kim, WJ
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Updates in Small Interfering RNA for the Treatment of Dyslipidemias. [PDF]
Curr Atheroscler Rep, 2023 Abstract Purpose of Review Atherosclerotic cardiovascular disease (ASCVD) is still the leading cause of death worldwide. Despite excellent pharmacological approaches, clinical registries consistently show that many people with dyslipidemia do not achieve optimal management, and many of them are treated with low-intensity
Carugo S +5 more
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Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants [PDF]
PharmaceuticalsRNA interference (RNAi) was originally regarded as a mechanism of eukaryotic post-transcriptional gene regulation mediated by small interfering RNA (siRNA)-induced sequence-specific RNA degradation.
Hara Kang +6 more
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Small Interfering RNA (siRNA) in Dyslipidemia: A Systematic Review on Safety and Efficacy of siRNA [PDF]
Journal of Experimental PharmacologySai Santhosha Mrudula Alla,1 Dhruv Jayeshkumar Shah,2 Shourya Meyur,3 Pahel Agarwal,4 Deekshitha Alla,1 Sai Lokesh Moraboina,5 Gayatri Vijay Ghadvaje,6 Ruth Getaneh Bayeh,7 Aparna Malireddi,1 Tess Shajan,8 Bodipudi Vineetha,5 Thalvayapati Sai Prudhvi,9 ...
Alla SSM +12 more
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Small interfering RNA; toward a new antiviral therapy [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2022 With the ability of viruses to mutate and introduce a high rate of diversity and continuous resistance to drug development, unique solutions are needed. RNA interference (RNAi) pathway as a natural defense mechanism mediated by plants, invertebrates, and
Engy Aziza
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