Results 151 to 160 of about 46,086 (263)

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, EarlyView.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects [PDF]

, 2017
Diamond, Michael S, et al,, Govero, Jennifer   +2 more
core   +2 more sources

N6‐Methyladenosine‐Modified circNEK11 Promotes Hepatocellular Carcinoma Progression via the miR‐1236‐3p/GPX2 Axis

Cancer Science, EarlyView.
circNEK11 is overexpressed in human HCC tissues, especially in recurrent tissues, and promotes the oncogenic functions of HCC cells. circNEK11 interacted with miR‐1236‐3p to stimulate GPX2 expression. Our findings highlight the potential of circNEK11 as a biomarker for HCC diagnosis and suggest that targeting circNEK11 may be an effective strategy for ...
Qian Li, Xu Huang, Yan Tong, Caiyu Yong, Minghui Song, Cunjie Chang, Heng Dong, Fangtian Bu, Shuanghong Yan, Jie Ying, Jianxiang Chen   +10 more
wiley   +1 more source

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

Cell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li, Jingya Zhang, Xu Wang, Xinru Wang, Yuyu Song, Xinyue Song, Xiuli Wang, Weiwei Cao, Chong Zhao, Jing Qi, Xiaodong Zheng, Yan Xing   +11 more
wiley   +1 more source

TSC22D1 is a newly identified inhibitor of insulin secretion in pancreatic beta cells

The FEBS Journal, EarlyView.
TSC22D1 acts downstream of glucose signaling and negatively regulates insulin secretion in pancreatic beta cells. Mechanistically, TSC22D1 interacts with FoxO1. Elevated glucose levels enhance the TSC22D1–FoxO1 interaction indirectly by increasing the protein abundance of TSC22D1. Importantly, TSC22D1 and FoxO1 not only physically associate but also co‐
Sümbül Yıldırım, Amit Mhamane, Svenja Lösch, Annika Wieder, Ezgi Ermis, Ann‐Christine König, Sevgican Yilmaz, Stefanie M. Hauck, Fatih Kocabas, Julia Szendroedi, Stephan Herzig, Bilgen Ekim   +11 more
wiley   +1 more source

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, EarlyView.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

pseudo‐GhFAD2‐1 Is a lncRNA Involved in Regulating Cottonseed Oleic and Linoleic Acid Ratios and Seed Size in Gossypium hirsutum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Long non‐coding RNAs (lncRNAs), defined as transcripts > 200 nt without protein‐coding capacity, play crucial regulatory roles in plant growth and development. While numerous lncRNAs exist in plants including cotton (Gossypium spp.), few are functionally characterised. G. hirsutum serves as both a premier fibre crop and significant oil source,
Haihong Chen, Yanjun Li, XianPeng Xiong, Xuan Liu, Fei Xue, Jie Sun, Qian‐Hao Zhu, Feng Liu   +7 more
wiley   +1 more source

MicroRNA‐Induced Gene Silencing (MIGS): A Tool for Multi‐Gene Silencing and Targeting Viruses in Plants

Plant Biotechnology Journal, EarlyView.
ABSTRACT Since its discovery, RNA interference (RNAi, also known as gene silencing) has been a key tool to downregulate gene expression in plants for a range of applications, including protection against viruses. Many of these applications require the silencing of multiple genes concomitantly.
Marie‐Emilie A. Gauthier, Kylie Shand, Satomi Hayashi, Peter M. Waterhouse, Roberto A. Barrero, Felipe F. de Felippes   +5 more
wiley   +1 more source

Precision RNAi in Tomato Using Synthetic Trans‐Acting Small Interfering RNAs Derived From Minimal Precursors

Plant Biotechnology Journal, EarlyView.
ABSTRACT RNA interference (RNAi) is a highly conserved gene silencing mechanism regulating gene expression at transcriptional and post‐transcriptional levels in plants. Synthetic trans‐acting small interfering RNAs (syn‐tasiRNAs) have emerged as powerful tools for highly specific and efficient gene silencing.
Ariel H. Tomassi, María Juárez‐Molina, Adriana E. Cisneros, Ana Alarcia, Francesca Orlando, Sara Toledano‐Franco, Silvia Presa, Antonio Granell, Alberto Carbonell   +8 more
wiley   +1 more source

Role of long non-coding RNA-mRNA interactions in resveratrol-mediated inhibition of ovarian cancer cell proliferation. [PDF]

Oncol Lett
Zhu W, Feng J, Zhang Y, Zhou Q, Huang H, Yang Y.   +5 more
europepmc   +1 more source