Results 151 to 160 of about 31,835 (252)

DICER-LIKE 4 functions in trans-acting small interfering RNA biogenesis and vegetative phase change in Arabidopsis thaliana.

Proceedings of the National Academy of Sciences of the United States of America, 2005
Zhixin Xie, E. Allen, April Wilken, J. C. Carrington   +3 more
semanticscholar   +1 more source

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A pathway is identified linking extracellular matrix stiffness to secretion via Src–FAK–AMPK–GBF1 signaling. Golgi‐localized GBF1 acts as a mechanotransducer whose phosphorylation controls post‐Golgi cargo sorting toward secretion or lysosomal degradation.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. del Mercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
wiley   +1 more source

In Vitro Efficacy of PEI-Derived Lipopolymers in Silencing of Toxic Proteins in a Neuronal Model of Huntington's Disease. [PDF]

Pharmaceutics
Morales LC, Modi L, Abbasi Dezfouli S, Rajendran AP, Kc R, Kadam V, Sipione S, Uludağ H.   +7 more
europepmc   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
wiley   +1 more source

Smoking‐Induced STC2+ Tumor Cells Drive Tumor‐Vascular Crosstalk in Laryngeal Squamous Cell Carcinoma via Spatial and Single‐Cell Transcriptomics

Advanced Science, Volume 13, Issue 5, 27 January 2026.
This study identifies a smoking‐induced mechanism in LSCC whereby nicotine activates the CHRNA5–JAK2/STAT3 axis to drive STC2 transcription. STC2 upregulates TGFBI, which interacts with endothelial ITGA5 to regulate vascular permeability and promote metastasis.
Yujie Shen, Lianchong Gao, Qiang Huang, Liang Zhou, Chengzhi Xu, Chunping Wu   +5 more
wiley   +1 more source

WAVY LEAF1, an Ortholog of Arabidopsis HEN1, Regulates Shoot Development by Maintaining MicroRNA and Trans-Acting Small Interfering RNA Accumulation in Rice1[C][W]

Plant Physiology, 2010
Masashi Abe, Takanori Yoshikawa, M. Nosaka, H. Sakakibara, Yutaka Sato, Y. Nagato, J. Itoh   +6 more
semanticscholar   +1 more source

Response to "The action of Arabidopsis DICER-LIKE2 in plant growth inhibition". [PDF]

Plant Cell
Nielsen CPS, Arribas-Hernández L, Brodersen P.   +2 more
europepmc   +1 more source

A database analysis method identifies an endogenous trans-acting short-interfering RNA that targets the Arabidopsis ARF2, ARF3, and ARF4 genes.

Proceedings of the National Academy of Sciences of the United States of America, 2005
L. Williams, Cristel C. Carles, Karen S. Osmont, J. Fletcher   +3 more
semanticscholar   +1 more source

CypA Mediates Non‐Small Cell Lung Cancer Chemoresistance by Attenuating Ferroptosis via Stabilizing SLC7A11

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Summary diagram for the role of CypA in chemoresistance in non‐small cell lung cancer (NSCLC). CypA is overexpressed in chemoresistance NSCLC and drives therapeutic evasion by competitively binding to the K37 site of SLC7A11, thereby blocking TRIM3 mediated K11‐linked ubiquitination and proteasomal degradation, ultimately inhibiting lipid peroxidation ...
Zhongcheng Wang, An Li, Ziwei Song, Xiangming Liu, Yong Ge, Zhiqiao Chen, Yuhui Liu, Boyu Zhang, Hao Zhang, Ting Lan   +9 more
wiley   +1 more source

Tobacco rattle virus infection alters Arabidopsis gene expression via virus-derived SiRNAs and host MiRNA network disruption. [PDF]

BMC Genomics
Yu L, Yang Z, Guo R, Zhou J, Meng Y, Shao C.   +5 more
europepmc   +1 more source