Results 171 to 180 of about 46,086 (263)

The Christianson syndrome protein, sodium hydrogen exchanger isoform 6, is required for fat accumulation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Nhe6 knockout mice (lower right) show age‐dependent weight loss resulting from lower fat accumulation in adipocytes, similar to Christianson's syndrome patients with NHE6 loss of function mutations. NHE6 is a Na+/H+ exchanger that regulates endosomal pH (pHendo) required for delivery of cargo, including fat and glucose ...
Ruby Gupta   +7 more
wiley   +1 more source

Vitamin‐Engineered Nanoplatforms in Precision Oncology: Integrating Immunotherapy, Delivery Systems, and Theranostics

open access: yesMedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Vitamin‐derived nanoplatforms advance precision oncology by augmenting immunotherapy through dendritic cell activation, T‐cell reprogramming, and TME remodeling to enhance antitumor immunity, while enabling targeted therapeutic delivery. These systems integrate theranostic capabilities using vitamin‐conjugated imaging probes for concurrent tumor ...
Ruowa Xu   +3 more
wiley   +1 more source

The epigenetic circle: feedback loops in the maintenance of cellular memory. [PDF]

open access: yesEpigenetics Chromatin
Tomljanović M   +3 more
europepmc   +1 more source

Unlocking grass leaf development: foundations for tunable cereal design

open access: yesNew Phytologist, Volume 248, Issue 4, Page 1655-1676, November 2025.
Summary The grass leaf plays a critical role in global food security, generating the carbon stores in cereal grains, which provide > 50% of global calories. As the global population grows, there is an urgent need to increase food production using fewer resources and to develop more resilient agricultural systems to withstand variable climate conditions
Trisha McAllister   +3 more
wiley   +1 more source

Phase Separation of TAF15 C‐Terminal LC Domain Enables RNA‐Binding Protein‐Mediated Transcriptional Regulation

open access: yesThe FASEB Journal, Volume 39, Issue 20, 31 October 2025.
This study revealed a critical role of the TAF15 C‐terminal low‐complexity (LC) domain in the control of TAF15‐mediated transcription. Phase separation of the C‐terminal LC domain allows for interactions with an RNA binding protein, hnRNPA0, which, in turn, enhances the transcriptional activity of TAF15.
Jiwon Lee, Ilmin Kwon
wiley   +1 more source

Classification of and detection techniques for RNAi-induced effects in GM plants. [PDF]

open access: yesFront Plant Sci
Diaz C   +6 more
europepmc   +1 more source

A Novel C19orf47‐AKT2 Chimeric RNA Generated by Cis‐Splicing of Adjacent Genes Is Associated With Glioblastoma Prognosis

open access: yesAnnals of Clinical and Translational Neurology, Volume 12, Issue 10, Page 2116-2129, October 2025.
ABSTRACT Objective Malignant gliomas pose significant therapeutic challenges. This study aimed to identify and characterize a novel chimeric RNA in glioma and assess its clinical and functional significance for precision treatment. Methods The C19orf47‐AKT2 chimeric RNAs were identified through RNA sequencing and validated by polymerase chain reaction.
Zihan Wang   +11 more
wiley   +1 more source

Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility

open access: yesAdvanced Therapeutics, Volume 8, Issue 10, October 2025.
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam   +5 more
wiley   +1 more source

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