Results 171 to 180 of about 46,086 (263)
Abstract figure legend Nhe6 knockout mice (lower right) show age‐dependent weight loss resulting from lower fat accumulation in adipocytes, similar to Christianson's syndrome patients with NHE6 loss of function mutations. NHE6 is a Na+/H+ exchanger that regulates endosomal pH (pHendo) required for delivery of cargo, including fat and glucose ...
Ruby Gupta+7 more
wiley +1 more source
Recovery of RNA-dependent RNA polymerase 6 gene-knockout phenotypes in Nicotiana benthamiana via in vivo generation of inverted repeat construct of the trans-acting short interference RNA3 sequence. [PDF]
Matsuo K.
europepmc +1 more source
Vitamin‐derived nanoplatforms advance precision oncology by augmenting immunotherapy through dendritic cell activation, T‐cell reprogramming, and TME remodeling to enhance antitumor immunity, while enabling targeted therapeutic delivery. These systems integrate theranostic capabilities using vitamin‐conjugated imaging probes for concurrent tumor ...
Ruowa Xu+3 more
wiley +1 more source
The epigenetic circle: feedback loops in the maintenance of cellular memory. [PDF]
Tomljanović M+3 more
europepmc +1 more source
Unlocking grass leaf development: foundations for tunable cereal design
Summary The grass leaf plays a critical role in global food security, generating the carbon stores in cereal grains, which provide > 50% of global calories. As the global population grows, there is an urgent need to increase food production using fewer resources and to develop more resilient agricultural systems to withstand variable climate conditions
Trisha McAllister+3 more
wiley +1 more source
This study revealed a critical role of the TAF15 C‐terminal low‐complexity (LC) domain in the control of TAF15‐mediated transcription. Phase separation of the C‐terminal LC domain allows for interactions with an RNA binding protein, hnRNPA0, which, in turn, enhances the transcriptional activity of TAF15.
Jiwon Lee, Ilmin Kwon
wiley +1 more source
Classification of and detection techniques for RNAi-induced effects in GM plants. [PDF]
Diaz C+6 more
europepmc +1 more source
ABSTRACT Objective Malignant gliomas pose significant therapeutic challenges. This study aimed to identify and characterize a novel chimeric RNA in glioma and assess its clinical and functional significance for precision treatment. Methods The C19orf47‐AKT2 chimeric RNAs were identified through RNA sequencing and validated by polymerase chain reaction.
Zihan Wang+11 more
wiley +1 more source
RNA elements and their biotechnological applications in plants. [PDF]
Lastovka F+3 more
europepmc +1 more source
Heterogeneity Landscape of Circulating Tumor Cells in Clinical Utility
This study reports the heterogeneity spectrum of circulating tumor cells. The factors involved in the spectrum promote CTCs to overcome barriers in the metastatic cascade but impact the clinical outcome of cancer patients. In summary, the heterogeneities in association with CTCs ultimately reduce patient survival and facilitate increasing mortality of ...
Md Kowsar Alam+5 more
wiley +1 more source