microRNA-Directed Phasing during Trans-Acting siRNA Biogenesis in Plants [PDF]
Cell, 2005 Plants and animals use small RNAs (microRNAs [miRNAs] and siRNAs) as guides for posttranscriptional and epigenetic regulation. In plants, miRNAs and trans-acting (ta) siRNAs form through distinct biogenesis pathways, although they both interact with target transcripts and guide cleavage.
Edwards Allen +3 more
semanticscholar +4 more sources
Identification of trans-acting siRNAs and their regulatory cascades in grapevine [PDF]
Bioinformatics, 2012 Abstract Motivation: Trans-acting small interfering RNAs (ta-siRNAs) play an essential role in the regulation of plant gene expression, but relevant reports are still limited. Bioinformatic analyses indicate that many ta-siRNA-producing loci (TASs) are present in plants, implying the existence of as yet undiscovered ta-siRNAs and ...
Changqing Zhang +3 more
semanticscholar +5 more sources
Bioinformatic prediction and experimental validation of a microRNA-directed tandem trans-acting siRNA cascade in Arabidopsis [PDF]
Proceedings of the National Academy of Sciences, 2007 Small RNAs play pivotal roles in regulating gene expression in higher eukaryotes. Among them, trans-acting siRNAs (ta-siRNAs) are a class of small RNAs that regulate plant development. The biogenesis of ta-siRNA depends on microRNA-targeted cleavage followed by the DCL4-mediated production of small RNAs phased in 21-nt increments relative ...
Ho‐Ming Chen +2 more
semanticscholar +4 more sources
A Trichinella spiralis serine protease triggers gut epithelial apoptosis and destroys the barrier integrity to mediate larval invasion. [PDF]
PLoS Neglected Tropical DiseasesBackgroundLarval invasion of gut mucosa is a crucial procedure in Trichinella spiralis infection. Previous studies showed that T. spiralis excretory-secretory proteins (ESP) disrupted gut epithelial integrity and promoted larval invasion by inducing ...
Qi Qi Lu +8 more
doaj +2 more sources
Artificial trans-Acting siRNAs Confer Consistent and Effective Gene Silencing [PDF]
Plant Physiology, 2008 Abstract Manipulating gene expression is critical to exploring gene function and a useful tool for altering commercial traits. Techniques such as hairpin-based RNA interference, virus-induced gene silencing, and artificial microRNAs take advantage of endogenous posttranscriptional gene silencing pathways to block translation of ...
María de la Luz Gutiérrez-Nava +4 more
openalex +4 more sources
Ancient trans-Acting siRNAs Confer Robustness and Sensitivity onto the Auxin Response [PDF]
Developmental Cell, 2016 ABSTRACTNovel developmental programs often evolve via cooption of existing genetic networks. To understand this process, we explored cooption of theTAS3tasiRNA pathway in the mossPhyscomitrella patens. We find an ancestral function for this repeatedly redeployed pathway in the spatial regulation of a conserved set of Auxin Response Factors.
Yevgeniy Plavskin +6 more
openalex +3 more sources
DRB4-Dependent TAS3 trans-Acting siRNAs Control Leaf Morphology through AGO7 [PDF]
Current Biology, 2006 trans-acting siRNAs (ta-siRNAs) are endogenous RNAs that direct the cleavage of complementary mRNA targets . TAS gene transcripts are cleaved by miRNAs; the cleavage products are protected against degradation by SGS3, copied into dsRNA by RDR6, and diced into ta-siRNAs by DCL4 .
Xavier Adenot +6 more
openalex +5 more sources
Endogenous trans-Acting siRNAs Regulate the Accumulation of Arabidopsis mRNAs [PDF]
Molecular Cell, 2004 Here we describe a set of endogenous short interfering RNAs (siRNAs) in Arabidopsis, some of which direct the cleavage of endogenous mRNAs. These siRNAs correspond to both sense and antisense strands of a noncoding RNA (At2g27400) that apparently is converted to double-stranded RNA and then processed in 21 nt increments.
Franck Vazquez +8 more
openalex +3 more sources
DICER-LIKE1 processedtrans-actingsiRNAs mediate DNA methylation [PDF]
Plant Signaling & Behavior, 2013 Small non-coding RNAs (sRNAs) emerge as exquisite molecules that are guided for transcriptional and posttranscriptional gene regulation in eukaryotes. As one class of most important sRNAs in plants, trans-acting small interfering RNAs (ta-siRNAs) initiate from microRNA (miRNA) - mediated cleavage of TAS gene transcripts and subsequently are stabilized ...
Liang Wu
openalex +3 more sources
SDE5, the putative homologue of a human mRNA export factor, is required for transgene silencing and accumulation of trans‐acting endogenous siRNA [PDF]
The Plant Journal, 2007 Inmaculada Hernández‐Pinzón +5 more
openalex +2 more sources