Results 71 to 80 of about 59,578 (250)

Apolipoprotein E mediates evasion from hepatitis C virus−neutralizing antibodies [PDF]

, 2016
Background & Aims Efforts to develop an effective vaccine against hepatitis C virus (HCV) have been hindered by the propensity of the virus to evade host immune responses. HCV particles in serum and in cell culture associate with lipoproteins, which
Bartenschlager, Ralf, Baumert, Thomas F., Crouchet, Emilie, Fauvelle, Catherine, Felmlee, Daniel J., Fofana, Isabel, Foung, Steven K.H., Habersetzer, François, Heydmann, Laura, Hiet, Marie-Sophie, Lee, JiYoung, Lefèvre, Mathieu, Magri, Andrea, Meuleman, Philip, Milne, Ross, Patel, Arvind H., Schuster, Catherine, Vercauteren, Koen, Zeisel, Mirjam B.   +18 more
core   +3 more sources

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Analysis of antisense expression by whole genome tiling microarrays and siRNAs suggests mis-annotation of Arabidopsis orphan protein-coding genes.

PLoS ONE, 2010
BackgroundMicroRNAs (miRNAs) and trans-acting small-interfering RNAs (tasi-RNAs) are small (20-22 nt long) RNAs (smRNAs) generated from hairpin secondary structures or antisense transcripts, respectively, that regulate gene expression by Watson-Crick ...
Casey R Richardson, Qing-Jun Luo, Viktoria Gontcharova, Ying-Wen Jiang, Manoj Samanta, Eunseog Youn, Christopher D Rock   +6 more
doaj   +1 more source

Harnessing Photo‐Energy Conversion in Nanomaterials for Precision Theranostics

Advanced Materials, EarlyView.
Harnessing photo‐energy conversion in nanomaterials enables precision theranostics through light‐driven mechanisms such as photoluminescence, photothermal, photoelectric, photoacoustic, photo‐triggered surface‐enhanced Raman scattering (SERS), and photodynamic processes. This review explores six fundamental principles of photo‐energy conversion, recent
Jingyu Shi, Yadi Fan, Qin Zhang, Yingying Huang, Mo Yang   +4 more
wiley   +1 more source

The Trans-Acting Short Interfering RNA3 Pathway and NO APICAL MERISTEM Antagonistically Regulate Leaf Margin Development and Lateral Organ Separation, as Revealed by Analysis of an argonaute7/lobed leaflet1 Mutant in Medicago truncatula[W][OPEN]

The Plant Cell, 2013
This work shows that a mutation of the ARGONAUTE7 ortholog (LOBED LEAFLET1) in Medicago truncatula causes lobed leaf margins and more widely spaced lateral organs.
Chuanen Zhou, Lu Han, C. Fu, J. Wen, Xiaofei Cheng, J. Nakashima, Junying Ma, Yuhong Tang, Yang Tan, M. Tadege, K. Mysore, G. Xia, Zeng‐Yu Wang   +12 more
semanticscholar   +1 more source

Conserved LBL1-ta-siRNA and miR165/166-RLD1/2 modules regulate root development in maize

Development, 2020
Root system architecture and anatomy of monocotyledonous maize is significantly different from dicotyledonous model Arabidopsis. The molecular role of non-coding RNA (ncRNA) is poorly understood in maize root development.
Vibhav Gautam, Archita Singh, Sandeep Yadav, Sharmila Singh, Pramod Kumar, Shabari Sarkar Das, A. Sarkar   +6 more
semanticscholar   +1 more source

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Divergent patterns of endogenous small RNA populations from seed and vegetative tissues of Glycine max

BMC Plant Biology, 2012
Background Small non-coding RNAs (smRNAs) are known to have major roles in gene regulation in eukaryotes. In plants, knowledge of the biogenesis and mechanisms of action of smRNA classes including microRNAs (miRNAs), short interfering RNAs (siRNAs), and ...
Zabala Gracia, Campos Edhilvia, Varala Kranthi K, Bloomfield Sean, Jones Sarah I, Win Hlaing, Tuteja Jigyasa H, Calla Bernarda, Clough Steven J, Hudson Matthew, Vodkin Lila O   +10 more
doaj   +1 more source

The endocannabinoid/cannabinoid receptor 2 system protects against cisplatin-induced hearing loss [PDF]

, 2018
Previous studies have demonstrated the presence of cannabinoid 2 receptor (CB2R) in the rat cochlea which was induced by cisplatin. In an organ of Corti-derived cell culture model, it was also shown that an agonist of the CB2R protected these cells ...
Asmita Dhukhwa, Debashree Mukherjea, Kelly Sheehan, Leonard P. Rybak, Leonard P. Rybak, Sandeep Sheth, Sumana Ghosh, Vickram Ramkumar, Vikrant Borse   +8 more
core   +4 more sources