Results 151 to 160 of about 18,877,401 (260)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

A Ferric Ammonium Citrate-Based Model of Iron Overload With Ferroptosis-Associated Readouts In C2C12 Myoblasts. [PDF]

J Vis Exp
Wacker EE, Puri G, Morrison JN, Blanc RS.   +3 more
europepmc   +1 more source

Notoginsenoside‐Fa mitigates vascular endothelial permeability via targeting SUGT1 to stabilize NLRP3 in a resting state

British Journal of Pharmacology, EarlyView.
Background and Purpose Notoginsenoside‐Fa (Noto‐Fa) is an emerging active compound derived from notoginseng with promise in treating cardiovascular diseases. The development of cardiovascular diseases is intricately linked to the damage of vascular endothelium and it is widely acknowledged that numerous chronic inflammation pathways, especially the ...
Xiao‐Ying Yu, Da‐Hao Mai, Xing‐Ming Zhong, Li‐Ting Huang, Lan‐Ting Fu, He‐Cai Wang, Ke Wang, Hai‐Yan Li, Qiu‐He Chen, Yang Chen   +9 more
wiley   +1 more source

Differential Effects of a First-in-Class IKK_α Inhibitor on Trabecular and Cortical Bone in a Human Prostate Cancer Xenograft Model. [PDF]

Calcif Tissue Int
Al-Jeffery A, Zeng F, Sophocleous A, Marino S, Ponzetti M, Capulli M, Paul A, Plevin R, Fowles ACM, Mackay SP, Rucci N, Idris AI.   +11 more
europepmc   +1 more source

Direct evidence implicating the asymmetrical dimethylarginine (ADMA)‐dimethylarginine dimethylaminohydrolase 1 (DDAH1) pathway in cerebrovascular dysfunction and stroke pathogenesis in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS), whereas dimethylaminohydrolase 1 (DDAH1) is primarily responsible for its metabolism. However, the roles of DDAH1 in cerebrovascular regulation are poorly understood. Furthermore, despite evidence that elevated ADMA levels are
Arun Flynn, Alexandra Riddell, Ashton Bernard, Jennifer Haggarty, Stefan Weidt, Jawza Alenazi, Erika Trabold, Delyth Graham, Laura B. Dowsett, James Leiper, Alyson A. Miller   +10 more
wiley   +1 more source

From Natural Product to Topical Antimicrobial Candidate: Evaluating <i>Nigella sativa</i> Seed Oil as a Broad-Spectrum Topical Antimicrobial in Multi-Tiered Preclinical Models. [PDF]

Pharmaceuticals (Basel)
Alnezary FS, Almutairi MS.
europepmc   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Identifying the angiogenic receptor expression in mantle cell lymphoma patients and murine models. [PDF]

Biomark Res
Singh S, Wang Y, Sircar A, Jindal U, Srour N, La Ferlita A, Distefano R, Soni A, Kumar D, Peralta-Camacho GJ, Zhao SL, Jafari H, Holter JC, Tinapple JW, Barlage JM, Kumar R, Berger M, Rahman K, Nezati R, Nath UK, Chaudhary N, Ranganathan P, Muthusamy N, Amador V, Li PK, Parekh S, Paik J, Baiocchi R, Song JW, Alinari L, Peterson BR, Epperla N, Jain N, Sehgal L.   +33 more
europepmc   +1 more source

A Melanoma Transplanted in Nude Mice Has Both Host‐ and Tumor‐Derived Blood Vessel‐ and Nerve‐Like Structures

Cancer Science, EarlyView.
Nestin‐driven green fluorescent protein (ND‐GFP) expressing peripheral blood vessels and nerves in the subcutaneous tissue of the ND‐GFP mice extended into the transplanted melanoma such that ND‐GFP was enhanced at the margin of the melanoma compared to the tumor‐free side.
Koya Obara, Azusa Sasaki, Yuko Hamada, Yutaro Kubota, Yusuke Aoki, Noriyuki Masaki, Michael Bouvet, Yasuyuki Amoh, Robert M. Hoffman   +8 more
wiley   +1 more source

A Defined Synbiotic Produces Immunomodulatory Metabolites, Engages Gut-Immune Pathways Relevant to Inflammaging, and Supports Healthy Aging in a Nematode Model. [PDF]

Int J Mol Sci
Green RS, Diaz-Infante Morales D, Schott EM, Charbonneau MR, Ballok AE.   +4 more
europepmc   +1 more source