Results 31 to 40 of about 3,811,879 (232)

Experimental Investigation on Cavity Characteristics during Water Entry of Disc-Headed Vehicle Assisted by Gas Jet Flow

水下无人系统学报
The trans-medium vehicle is expected to quickly and stably break the free liquid surface. In addition, there are some problems in the trans-medium process, such as the damage to structures and instruments caused by the high impact load, cavity collapse ...
Zikun ZHEN, Zhihui ZOU, Yunhua JIANG
doaj   +1 more source

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

Advanced Science, EarlyView.
This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui   +25 more
wiley   +1 more source

Review of the Development on Load Reduction Methods for Water Entry of High-Speed Vehicles

水下无人系统学报
The water entry process of high-speed vehicles involves complex fluid-structure interaction between multiple phase flows and vehicles, which can result in transient impact loads and potential structural damage.
Wei ZHENG, Qiang LI, Xudong FAN, Xujian LÜ   +3 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

Coupling Dynamics Study on Multi-Body Separation Process of Underwater Vehicles

Drones
Based on the Newton-Euler method, a coupling rigid-body dynamics model of a Trans-Medium Vehicle (TMV) separating from an Unmanned Underwater Vehicle (UUV) has been established. The modeling is based on the “holistic method” and “Kane” ideas respectively,
Jiahui Chen, Yanhua Han, Ruofan Li, Yong Zhang, Zhenmin He   +4 more
doaj   +1 more source

SerpinA3 is an Endogenous TGF‐β Receptor Antagonist that Attenuates Cardiac Fibroblast Activation and Fibrotic Remodeling

Advanced Science, EarlyView.
SerpinA3 acts as an endogenous TGF‐β receptor antagonist that binds to the extracellular domain of TGFR‐1, thereby preventing TGFR‐1–TGFR‐2 complex formation. This receptor‐level blockade suppresses TGF‐β/Smad2/3 signaling, attenuates cardiac fibroblast activation, and extracellular matrix deposition, and ultimately alleviates pressure overload–induced
Hui Wang, Jieyu Cui, Chunlu Huang, Wanyi Guo, Tong Liu, Yi Zhu, Shuai Shao, Kangyin Chen, Jinlong He, Qiankun Bao   +9 more
wiley   +1 more source

Disruption management of the vehicle routing problem with vehicle breakdown [PDF]

, 2011
This paper introduces a new class of problem, the disrupted vehicle routing problem (VRP), which deals with the disruptions that occur at the execution stage of a VRP plan.
Eglese, R W, Mu, Q, Fu, Z, Lysgaard, J
core   +4 more sources

Improved Information Processing for Cooperative Vehicle Safety Applications [PDF]

, 2006
Current Vehicle-to-Vehicle and Vehicle-to-Roadside communication based on IEEE 802.11 cannot guarantee a reliable dissemination of situational information which is required for Situation-Aware Driver Assistance Systems.
Strang, Thomas, Frank, Korbinian, Röckl, Matthias, Robertson, Patrick   +3 more
core  

Dynamics Simulation of Remotely Operated Vehicle-Fiber Optic Micro Cable System [PDF]

, 2008
Li Q, Xu H, Zhang Q, Wang X, Li ZG. Dynamics Simulation of Remotely Operated Vehicle-Fiber Optic Micro Cable System.
Li, ZhiGang, Li ZG(李智刚), Xu, Hongli, Zhang QF(张奇峰), Qiang Li, Li, Qiang ; https://orcid.org/, Wang, Xiaohui, Xiaohui Wang, Zhigang Li, Wang XH(王晓辉), Hongli Xu, Qifeng Zhang, Zhang, Qifeng, Li Q(李强), Xu HL(徐红丽)   +14 more
core   +1 more source

Restoration of m6A‐Modified circPSMB1 Suppresses Chordoma Progression and Enables Local Nanotherapeutic Intervention

Advanced Science, EarlyView.
An m6A‐modified circRNA, circPSMB1, is identified as a tumor suppressor in chordoma. METTL3‐dependent m6A promotes circPSMB1 interaction with HNRNPA2B1, limiting c‐MYC expression and malignant progression. An injectable HMnO2‐based nanohydrogel enables local circPSMB1 delivery and tumor microenvironment‐responsive therapy, offering a promising strategy
Yingchuang Tang, Liang Qiu, Xingbang Ruan, Yihan Shi, Ye Wang, Hanwen Li, Kai Zhang, Kangwu Chen   +7 more
wiley   +1 more source