Results 21 to 30 of about 5,509,803 (257)

Diazido mixed-amine platinum(IV) anticancer complexes activatable by visible-light form novel DNA adducts [PDF]

, 2013
Platinum diam(m)ine complexes, such as cisplatin, are successful anticancer drugs, but suffer from problems of resistance and side-effects. Photoactivatable PtIV prodrugs offer the potential of targeted drug release and new mechanisms of action.
Bancroft, Brabec, Brabec, Brabec, Butler, Caradonna, Coluccia, Dhara, Eastman, Eastman, Farrell, Farrer, Farrer, Fichtinger-Schepman, Guddneppanavar, Hall, Hamers, Harper, Intini, Jamieson, Kasparkova, Kasparkova, Kauffman, Keck, Kelland, Lau, Lemaire, Mackay, Mackay, Mackay, Najajreh, Ohndorf, O’Dwyer, Pantoja, Phillips, Pracharova, Pregosin, Prokop, Reedijk, Ronconi, Salassa, Salassa, Salassa, Salassa, Siddik, Stehlíková, Still, Suchánková, Tai, Vinje, Vlček, Wang, Westendorf, Westendorf, Westendorf, Wong, Yao, Zenker   +57 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Functional characterization of synthetic leukotriene B and its stereochemical isomers. [PDF]

, 1981
Leukotriene B (LTB), a potent lipid chemotactic factor for neutrophils, is 5S,12R-dihydroxy-6,14-cis,8,10-trans-eicosatetraenoic acid (Fig 1), based upon direct comparison of natural LTB with synthetic 5S,12R-dihydroxy-6,8,10,14-eicosatetraenoic acid (5 ...
Austen, K, Corey, E, Drazen, J, Goetzl, Edward, Lewis, R, Soter, N   +5 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Ruminal bacterial community change in response to diet-induced variation of ruminal trans-10 fatty acids [PDF]

, 2011
Trans fatty acids (FA) are produced during the biohydrogenation of linoleic acid in the rumen. Because of their health‐promoting properties, trans‐11 isomers, which are usually the most abundant biohydrogenation intermediates, are most desirable (1 ...
Cauquil, Laurent, Combes, Sylvie, Enjalbert, Francis, Troegeler-Meynadier, Annabelle, Zened, Asma   +4 more
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A deficiency of documentation in translation historiography in Spain: reflections about performed but unpublished (Austrian) theatre [PDF]

, 2013
The aim of this paper is to underline the importance of recovering translated but not published literature in Spain so as to contribute exhaustively to translation history.
Maciá, Marina (trans.), Ruiz, Inmaculada (trans.), Serrano Bertos, Elena   +2 more
core   +1 more source

Highly alkylated cyclohexanes. X-Ray crystal structures, force-field calculations, and conformations of cis/trans-1,4-disubstituted cyclohexane isomers [PDF]

, 1988
The structures of mesylated cis- and trans-tetramethylshisool cis- 2 and trans-2 have been elucidated by single-crystal X-ray techniques. In cis-2 the isopropenyl group adopts an axial position in the crystal, and the structural data obtained are in good
Burkert, Hasel, Hoffmann, Jefford, Schneider, Waegell   +5 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source