Results 81 to 90 of about 17,478,568 (370)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Purification and characterization of a thermophilic NAD+‐dependent lactate dehydrogenase from Moorella thermoacetica

open access: yesFEBS Open Bio, EarlyView.
The thermophilic acetogenic model organism Moorella thermoacetica can utilize lactate as substrate. The formation of lactate by reduction of pyruvate is energetically favorable, but the reverse reaction, the oxidation of lactate to pyruvate with NAD+ as electron acceptor is challenging.
Florian P. Rosenbaum, Volker Müller
wiley   +1 more source

Efficient and privacy-preserving decentralized energy trading scheme in a blockchain environment

open access: yesEnergy Reports, 2022
Blockchain technology provides the possibility for the realization of decentralized energy trading. However, the blockchain confronts privacy risks and efficiency issues, which hinder its application in energy trading.
Jingya Dong   +5 more
doaj  

RDQN: ensemble of deep neural network with reinforcement learning in classification based on rough set theory for digital transactional fraud detection

open access: yesComplex & Intelligent Systems, 2023
All financial sectors are facing the most common frauds, which are digital transactional frauds. Fraudsters have always engaged in illegal activities such as stealing personal information and logging in with unauthorised credentials.
Chandana Gouri Tekkali   +1 more
doaj   +1 more source

Tomen: Application of Bitcoin Transaction Based on Tor [PDF]

open access: yesarXiv, 2021
Bitcoin has emerged in 2008, and after decades of development, it has become the largest trading currency by far. The core of the blockchain is to ensure the anonymity of user transactions. As more and more analysis algorithms for blockchain transactions appear, the anonymity of the blockchain is increasingly threatened. We propose Tomen, an encryption
arxiv  

Toward Scalable Transaction Processing

open access: yesProceedings of the VLDB Endowment, 2013
Designing scalable transaction processing systems on modern multicore hardware has been a challenge for almost a decade. The typical characteristics of transaction processing workloads lead to a high degree of unbounded communication on multicores for ...
A. Ailamaki   +3 more
semanticscholar   +1 more source

Red blood cells could protect miRNAs from degradation or loss thanks to Argonaute 2 binding

open access: yesFEBS Open Bio, EarlyView.
The present work investigates the presence and the stability of miRNAs into RBCs, both native and engineered. The observed stability is due to the Ago2 bound resulting in minimal RISC. Indeed, if the miRNA‐Ago2 complex is present, miRNAs are protected from release or degradation and they are biologically active. Thus, RBCs can act as miRNA carriers for
Elena Perla   +4 more
wiley   +1 more source

Chiller: Contention-centric Transaction Execution and Data Partitioning for Modern Networks [PDF]

open access: yes, 2018
Distributed transactions on high-overhead TCP/IP-based networks were conventionally considered to be prohibitively expensive and thus were avoided at all costs. To that end, the primary goal of almost any existing partitioning scheme is to minimize the number of cross-partition transactions.
arxiv   +1 more source

Enhanced discovery of bacterial laccase‐like multicopper oxidase through computer simulation and metagenomic analysis of industrial wastewater

open access: yesFEBS Open Bio, EarlyView.
We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui   +5 more
wiley   +1 more source

Concurrency Conflict Modeling for Asynchronous Processing in Blockchain-Based Transactive Energy Systems

open access: yesMathematics
Blockchain is widely adopted for decentralized transaction management in systems like Transactive Energy (TE). Unfortunately, conventional blockchains with sequential models and restrictive participation rules do not meet energy sector requirements. High
Fabiola Marcos Solis   +3 more
doaj   +1 more source

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