Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury
Advanced Science, EarlyView.This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng +10 more
wiley +1 more source
Venetoclax Plus Blinatumoma as First Line Therapy for Newly Diagnosed Ph-Negative B-Cell Acute Lymphoblastic Leukemia. [PDF]
Blood Lymphat CancerLei Y +11 more
europepmc +1 more source
Regulation of Branched Chain Amino Acid Transaminase Formation During the Growth of Pseudomonas fluorescens UK-1. [PDF]
, 1972 M. Puukka +4 more
openalex +1 more source
Development of an Amine Transaminase-Lipase Cascade for Chiral Amide Synthesis under Flow Conditions
, 2023 Antía Pintor +4 more
openalex +1 more source
GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer
Advanced Science, EarlyView.Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello +10 more
wiley +1 more source
Clinical outcomes after laparoscopic left hemihepatectomy with and without biliary duct exploration. [PDF]
BMC SurgWan Z, Wu L, Liu X, Wan R, Wang X.
europepmc +1 more source
Distant precursors of benzylisoquinoline alkaloids and their enzymatic formation [PDF]
, 1987 Rüffer, Martina, Zenk, Meinhart H.
core +1 more source
Study of Carotid Atherosclerosis in Non-alcoholic Fatty Liver Disease Patients and Its Correlation With Serum Transaminases [PDF]
Akshayaa K Aggarawal, Abhishek Deepak
openalex +1 more source
USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer
Advanced Science, EarlyView.USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen +9 more
wiley +1 more source
Metabolic burden-based clinical-radiological model for predicting postoperative recurrence of hepatitis B-related hepatocellular carcinoma. [PDF]
Insights ImagingZheng B +6 more
europepmc +1 more source