Regulating Enzyme Activity via Microaggregates Mediated by Phase Separation
An enzyme‐sequestration strategy for combating postoperative pancreatic fistula (POPF) is developed, employing a D‐peptide called DPMD to induce liquid–solid phase separation (LSPS) of pancreatic proteases. This LSPS‐driven microaggregate approach effectively isolates trypsin and chymotrypsin from their substrates, thereby reducing pancreatic fluid ...
Yang Wang+7 more
wiley +1 more source
Correction: Chen et al. Metabolomics-Based Study on the Anticonvulsant Mechanism of <i>Acorus tatarinowii</i>: GABA Transaminase Inhibition Alleviates PTZ-Induced Epilepsy in Rats. <i>Metabolites</i> 2025, <i>15</i>, 175. [PDF]
Chen L, Li J, Fang C, Wang J.
europepmc +1 more source
Transaminase Activity in Sheep Rumen Content
Hiroyuki Tsubota, Sadao HOSHINO
openalex +1 more source
Enhancing radiosensitization, modulating the tumor immune microenvironment, and ensuring complete resection are crucial for colorectal cancer (CRC) treatment. This study presents a multifunctional NIR‐II fluorescent nanoprobe, RVLu@ICG, which enhances radiosensitization, remodels the tumor immune microenvironment, and enables precise image‐guided ...
Yongying Dang+10 more
wiley +1 more source
Flexible Parametric Survival Modeling of Transaminases as Predictive Biomarkers for Non-Alcoholic Fatty Liver Disease: A Retrospective Longitudinal Study (2012-2022). [PDF]
Ghanem AS+5 more
europepmc +1 more source
Studies of Serum Transaminases in Xeroderma Pigmentosum
H El-Hefnawi, M. F. S. El-Hawary
openalex +1 more source
The ferroheme (FH) and exceedingly small magnetic iron oxide nanoparticles (IO) loaded mesoporous calcium peroxide nanocuboid (MCPNC) with conjugation of hyaluronic acid (HA) possesses exceptional capability of tumor accumulation, and enhances therapeutic efficacy of tumors based on the mechanism of promoting a positive feedback loop of Fenton reaction
Qingdeng Fan+17 more
wiley +1 more source
Association of serum lactate dehydrogenase levels with non-alcoholic fatty liver disease and advanced hepatic fibrosis in the United States: a cross-sectional study using NHANES data from 2007 to 2018. [PDF]
Zhang X+5 more
europepmc +1 more source
Fibrosis‐3 index (FIB‐3) can stratify the risk of the survival and the recurrence‐free survival. The FIB‐3 index is a reliable, age‐independent tool for assessing liver fibrosis and prognosis in HCC patients post‐hepatectomy. Its use may improve clinical outcomes and support personalized treatment strategies. Abstract Background Liver fibrosis is a key
Yuki Imaoka+13 more
wiley +1 more source
Despite initial challenges, the healthcare system of Japan effectively managed rectal cancer surgeries during and after the COVID‐19 pandemic. Robotic surgery became more widely adopted, and complication rates improved, demonstrating resilience and adaptability in surgical care.
Ryo Seishima+13 more
wiley +1 more source