Results 241 to 250 of about 292,424 (340)

Abnormalities of serum transaminase activities in healthy blood donors.

, 1985
Yasuo Kanda, Hironobu Namiki, Hiroko Miyazawa, Hiroshi Kawahira, Mozumi Hoshino, Mao Abe, Takiko Ishino, Takeyoshi Ito, Masumi Baba, Takahiko Ozaki, Yasuyuki Arakawa, Y Amemiya   +11 more
openalex   +2 more sources

Biomimetic Nanomedicine for Senescence‐Modulated Immune Activation Enhances Immunotherapy Efficacy in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A multifunctional mPDZM nanoplatform is developed in this study. mPDZM integrates chemotherapy‐induced senescence, selective senolysis, and STING‐mediated immune activation. mPDZM effectively clears senescent tumor cells, remodels the tumor immune microenvironment, and enhances antitumor T‐cell responses.
Shiji Fang, Liyun Zheng, Bin Lin, Jiale Chen, Dehai Hou, Yiming Ding, Mengzhu Han, Pan Qin, Mengyuan Wang, Xiaoju Guo, Yeyu Zhang, Gaofeng Shu, Fazong Wu, Jianfei Tu, Minjiang Chen, Zhongwei Zhao, Zhuang Liu, Jiansong Ji   +17 more
wiley   +1 more source

Association of chemotherapy and stoma features with peristomal skin disorders in rectal cancer patients. [PDF]

Sci Rep
Shiraishi T, Nishizawa Y, Nakajima M, Kado R, Ogawa H, Naomi S, Owada Y, Enomoto T, Yazawa S, Hamahata Y, Isogami Y, Kitagawa K, Sakamoto M, Enomoto H, Egawa A, Kitaguchi D, Hasegawa H, Ikeda K, Tsukada Y, Ito M.   +19 more
europepmc   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Clinical and biological features of acute hepatic cytolysis in dengue fever: a study from Sourô Sanou University hospital, Bobo-Dioulasso. [PDF]

IJID Reg
Jacques Z, Abdoulaye S, Tôh S, Delphine ZP, Arnaud DE, Dogbèponé S, Arsène OG, Ismael D, Mamoudou S, Apoline SK, Armel P, Appolinaire S.   +11 more
europepmc   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Utilization of Liver Grafts From Donation After Circulatory Death Donors on Extracorporeal Membrane Oxygenation Support Using Normothermic Regional Perfusion. [PDF]

Transplant Direct
Jacques A, Walker O, Monday K, Schwartz G, Richards G, Duncan M, Bayer J, Lee SH, Gupta A, Martinez E, Danobeitia JS, Testa G, Wall AE.   +12 more
europepmc   +1 more source

EFFECTS OF SOME DRUGS ON THE γ-AMINOBUTYRIC ACID TRANSAMINASE AND THE SUCCINIC SEMIALDEHYDE DEHYDROGENASE OF RAT BRAIN

, 1961
Keiji Nakamura, Frederick Bernheim
openalex   +1 more source

Synthesis of Bispecific Conjugates by ADP‐Ribosyl Cyclases

Advanced Science, EarlyView.
Genetic fusion of a CD38 enzymatic domain to antibody scaffolds allows site‐specific conjugation of small‐molecule ligands. Using this approach, a PSMA ligand DUPA is conjugated with an anti‐human CD3 Fab antibody. The resulting bispecific anti‐CD3‐DUPA conjugate facilitates recruitment and activation of cytotoxic T cells against PSMA‐expressing ...
Sunny H. Kim, Arshad J. Ansari, Lei Zhang, Guoyun Kao, Thuc Oanh Hoang, Zeyu Zhang, Srinivasarao Singireddi, Benjamin B. Katz, Yong Zhang   +8 more
wiley   +1 more source

Efficacy of Semaglutide in Pediatric Patients With Bardet-Biedl Syndrome and Alström Syndrome. [PDF]

JCEM Case Rep
Dauleh H, Mohammed I, Hussain K.
europepmc   +1 more source