Results 241 to 250 of about 134,646 (295)

Protective Effect of Hordenine on Concanavalin A-Induced Hepatic Injury. [PDF]

open access: yesJ Inflamm Res
Liu Y   +8 more
europepmc   +1 more source

Protective effects of allicin against stanozolol‐induced cardiotoxicity: Physiological and histopathological evidence in a rabbit model

open access: yesAnimal Models and Experimental Medicine, EarlyView.
There are many forms of anabolic steroids, including stanzolo (Winstrol), which are popular for their muscle‐building effects but dangerous to the heart. This present work is aimed at evaluating the pharmacological impact of allacin, a natural attribute obtained from garlic on obstructing cardiac injury in rabbits that received stanzolo.
Mohammed Hayder Asker   +3 more
wiley   +1 more source

Long‐term immunosuppression of rabbits through oral tacrolimus administration

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Oral gavage of rabbits with 1.5 mg/kg/d of tacrolimus allows for an efficient long‐term (1 year) immunosuppression with minimal side effects and no loss of animals. lmmunosuppressed rabbits are a convenient animal model to investigate the long‐term efficacy of human allografts in vivo.
Alexane Thibodeau   +4 more
wiley   +1 more source

Achieving scalable expansion of therapeutic porcine hepatocytes in vivo through serial transplantation

open access: yesAnimal Models and Experimental Medicine, EarlyView.
This represents the first serial hepatocyte transplantation pig model designed to investigate the massive hepatocyte proliferation in vivo. Leveraging this novel model, we achieved serial hepatocyte transplantation and regeneration in a porcine model, where the transplanted hepatocytes effectively repopulated the livers of two‐generation model pigs in ...
Zhiqiang Han   +10 more
wiley   +1 more source

Cationic Nanoparticles Mitigate Chemotherapy‐Induced Peripheral Neuropathy

open access: yesAdvanced NanoBiomed Research, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN), caused by chemodrugs like paclitaxel (PTX), leads to severe neuropathic pain. This study evaluates PTX‐loaded PAMAM‐Chol nanoparticles (PTX‐NPs) to alleviate CIPN. PTX‐NPs achieve 99% drug‐loading efficiency, reduce neurotoxicity, and in murine models, decrease cold allodynia by 85% while restoring ...
Divya Bhansali   +7 more
wiley   +1 more source

Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning

open access: yesAdvanced NanoBiomed Research, EarlyView.
Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang   +7 more
wiley   +1 more source

Severe rhabdomyolysis in an infant due to fatty acid oxidation disorder: a case report. [PDF]

open access: yesJ Med Case Rep
Krug A   +6 more
europepmc   +1 more source

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