Results 21 to 30 of about 251,409 (391)
Frontiers in Physiology, 2022 Background/Purpose: Nonalcoholic fatty liver disease (NAFLD) constitutes a spectrum of liver diseases associated with various metabolic disorders. Exercise interventions reportedly manage the clinical outcomes of NAFLD, but their efficacy depends on ...
Feng Hong +7 more
doaj +1 more source
Рациональная фармакотерапия в кардиологии, 2017 Russian physicians often afraid to use statins in patients with high cardiovascular risk and nonalcoholic fatty liver disease (NAFLD) or other hepatobiliary diseases, especially in cases when elevated levels of serum transaminases are detected. To expand
S. N. Bel'diev
doaj +1 more source
A Biochemical Logic Approach to Biomarker-Activated Drug Release [PDF]
J. Mater. Chem. 22, 19709-19717 (2012), 2013 The present study aims at integrating drug-releasing materials with signal-processing biocomputing systems. Enzymes alanine transaminase (ALT) and aspartate transaminase (AST)---biomarkers for liver injury---were logically processed by a biocatalytic cascade realizing Boolean AND gate. Citrate produced in the system was used to trigger a drug-mimicking
arxiv +1 more source
Anticoagulants and Transaminase Elevation [PDF]
Circulation, 2006 Case 1: Mr F., a 65-year-old man with hypertension and atrial fibrillation, began long-term anticoagulation with warfarin 1 year ago. He presented with a 1-week history of nausea, anorexia, jaundice, and altered mental status. His laboratory workup showed elevated serum transaminases and direct bilirubin.
Nipun Arora, Samuel Z. Goldhaber
openaire +3 more sources
Biocatalysis as Useful Tool in Asymmetric Synthesis: An Assessment of Recently Granted Patents (2014–2019) [PDF]
, 2019 The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical fields are interconnected and synergized. A way to depict that innovation is by conducting a survey on patent activities.
Alcántara, Andrés R. +2 more
core +3 more sources
Catalysts, 2018 Chiral amines are important components of 40-45% of small molecule pharmaceuticals and many other industrially important fine chemicals and agrochemicals.
Mahesh D. Patil +3 more
semanticscholar +1 more source
Molecules, 2023 Pyridoxal-5′-phosphate (PLP)-dependent transaminases are highly efficient biocatalysts for stereoselective amination. D-amino acid transaminases can catalyze stereoselective transamination producing optically pure D-amino acids.
Sofia A. Shilova +9 more
doaj +1 more source
Pharmacologic modulation of experimental postischemic hepatic function [PDF]
, 1989 The present study, evaluated and compared the effects of SRI 63-441, a potent platelet activating factor antagonist, superoxide dismutase (SOD), an oxygen free radical scavenger, and ibuprofen, a cyclooxygenase inhibitor on hepatic function after 90 ...
Makowka, L +5 more
core +2 more sources
OncoTargets and Therapy, 2019 Background Numerous studies have reported the association between pretreatment serum aspartate transaminase to alanine transaminase (AST/ALT) ratio and prognosis in multiple cancers.
Jiayuan Wu +4 more
semanticscholar +1 more source
Transaminase biocatalysis: optimization and application
, 2017 Transaminases (TAs) are one of the most promising biocatalysts in organic synthesis for the preparation of chiral amino compounds. The concise reaction, excellent enantioselectivity, environmental friendliness and compatibility with other enzymatic or ...
Fei Guo, Per Berglund
semanticscholar +1 more source