Results 81 to 90 of about 286,762 (263)

Liver transplantation before 1 year of age [PDF]

, 1987
Since 1981, 20 infants younger than 1 year of age received 26 orthotopic liver transplants. Immunosuppression was with cyclosporine and corticosteroids. Thirteen (65%) of the reciplents were discharged from the hospital.
Ascher, Baburao Koneru, Carlos O. Esquivel, Frederick Karrer, Gartner, Gordon, Iwatsuki, Kasai, Leonard Makowka, Robert D. Gordon, Rosenthal, Satoru Todo, Shunzaburo Iwatsuki, Starzl, Starzl, Starzl, Starzl, Thomas E. Starzl, Wallis J. Marsh   +18 more
core   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Termoativação da transaminase glutâmico oxaloacética

Memorias do Instituto Oswaldo Cruz, 1973
Estudou-se a atividade da transaminase glutâmico oxaloacética (TGO) em diferentes tecidos (fígado, músculo, rim, pulmão, baço e soro sanguíneo) de ratos e de soro humano.
Hélion Póvoa Júnior, Paulo Cesar Carvalho de Almeida, Orlando O. Alves, Neusa Marcondes   +3 more
doaj   +1 more source

Reconstitution of hepatitis B virus (HBV)-specific T cell responses with treatment of human immunodeficiency virus/HBV coinfection [PDF]

, 2003
Liver-related mortality is an increasing problem in human immunodeficiency virus (HIV)/hepatitis B virus (HBV)-coinfected patients receiving highly active antiretroviral therapy (HAART).
Bertoletti, A, Gilson, RJ, Lascar, RM, Lopes, AR, Maini, MK   +4 more
core   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Caracterização de variedades de batata doce (Ipomoea batatas L.) através de descritores morfológicos e isoenzimáticos Morphological and isoenzymatic characterization of sweet potato (Ipomoea batatas L.)

Ciência Rural, 2000
Ocorre grande variabilidade no germoplasma de batata-doce disponível no Rio Grande do Sul, mas nem todas populações podem ser caracterizadas através de aspectos morfológicos, havendo necessidade de recorrer a outros métodos, como análise de isoenzimas ...
Eliane Augustin, Alseny Garcia, Beatriz Helena Gomes Rocha   +2 more
doaj   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Liver Dysfunction in Hypothyroid Non-Pregnant Women

Annals of Abbasi Shaheed Hospital and Karachi Medical & Dental College, 2018
Objective: To evaluate the effects of under secretion of thyroid hormones and its  relation  with  liver markers i.e. alanine transaminase (ALT) and aspartate transaminase (AST) in non-pregnant women.
Mohammad Yousaf, Zahoor Ahmad
doaj   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Serum Transaminase in Duchenne Dystrophy

Pediatric Neurology Briefs, 2011
Researchers at Children’s Hospital Boston, MA, have shown a linear relationship between serum CPK and serum ALT and AST and a logarithmic relationship between serum enzyme levels and age for boys with Duchenne (n=46) or Becker (n=9) muscular dystrophy ...
J Gordon Millichap
doaj   +1 more source