Excess portal venous long-chain fatty acids induce syndrome X via HPA axis and sympathetic activation [PDF]
, 2000 We tested the hypothesis that excessive portal venous supply of long-chain fatty acids to the liver contributes to the development of insulin resistance via activation of the hypothalamus-pituitary-adrenal axis (HPA axis) and sympathetic system.
Benthem, Lambertus, +7 more
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Transaminase Inhibition by Decaborane
Experimental Biology and Medicine, 1968 The use of the boron hydrides, pentaborane and decaborane, in recent years as high energy propellants has stimulated interest in the mechanism(s) by which this class of compounds expresses its toxic effects.Boron hydrides are known to cause marked derangements in the biochemical and functional relationships of the central nervous system (1).
W N, Scott +3 more
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Minimal hepatic toxicity of Onyx-015: spatial restriction of coxsackie-adenoviral receptor in normal liver. [PDF]
, 2007 We administered an adenoviral vector, Onyx-015, into the hepatic artery of patients with metastatic colorectal cancer involving the liver. Thirty-five patients enrolled in this multi-institutional phase I/II trial received up to eight arterial infusions ...
Au, T +5 more
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Low-Level Saturated Fatty Acid Palmitate Benefits Liver Cells by Boosting Mitochondrial Metabolism via CDK1-SIRT3-CPT2 Cascade. [PDF]
, 2020 Saturated fatty acids (SFAs) (the "bad" fat), especially palmitate (PA), in the human diet are blamed for potential health risks such as obesity and cancer because of SFA-induced lipotoxicity. However, epidemiological results demonstrate a latent benefit
Candas-Green, Demet +9 more
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Nonalcoholic steatohepatitis pharmacotherapy and predictors of response: dual role of aminotransferases as biosensors of metabolism and biomarkers of histological improvement [PDF]
, 2019 Nonalcoholic steatohepatitis (NASH)—the severe histological form of nonalcoholic fatty liver disease (NAFLD)—is regarded as a major health problem worldwide (1,2).
Pirola, Carlos José +1 more
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Frontiers in Plant Science, 2018 Phosphoserine aminotransferase (PSAT) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the conversion of 3-phosphohydroxypyruvate (3-PHP) to 3-phosphoserine (PSer) in an L-glutamate (Glu)-linked reversible transamination reaction.
Bartosz Sekula +2 more
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Tolvaptan-induced isolated elevation of bilirubin in a patient with Gilbert syndrome
SAGE Open Medical Case Reports, 2023 Tolvaptan is the current standard of treatment for autosomal dominant polycystic kidney disease. It operates by acting on V2 receptors and blocks vasopressin interactions, causing a reduction in the rate of renal cyst growth and preserving kidney ...
Matthew Nguyen +4 more
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The International Working Group on Neurotransmitter related Disorders (iNTD): A worldwide research project focused on primary and secondary neurotransmitter disorders [PDF]
, 2016 INTRODUCTION: Neurotransmitters are chemical messengers that enable communication between the neurons in the synaptic cleft. Inborn errors of neurotransmitter biosynthesis, breakdown and transport are a group of very rare neurometabolic diseases ...
Cortès-Saladelafont, Elisenda +17 more
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Measurement of Transaminases in Serum
Nature, 1960 WITH the growing emphasis on the study of glutamic oxaloacetic and glutamic pyruvic transaminases of the serum, both in the diagnosis and the prognosis of a large number of pathological conditions, particularly in cardiovascular and hepatic diseases, a need for a simple and accurate method for the measurement of these transaminases is apparent.
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TRANSAMINASE IN HUMAN SEMEN [PDF]
Reproduction, 1967 Summary. Determinations of aspartate and alanine aminotransferase activity in human semen were carried out by the spectrophotometric and colorimetric methods. It was found that the occurrence of interfering substances in semen makes the spectrophotometric method unsuitable without prior partial purification of the enzyme.
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