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Transaminases: oldies but goldies. A narrative review.
Minerva Gastroenterologica e Dietologica, 2020INTRODUCTION Worldwide, the patients are tested for acute and chronic diseases using a series of basic blood assays. The most common liver tests are serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), also called transaminases ...
A. Suciu +4 more
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The Journal of Parasitology, 1960
Although transaminases were identified in animal tissues as early as 1937, very few observations have been made on these systems in parasitic helminths. Daugherty (1952) found that homogenates of the liver fluke, Fasciola hepatica, contained very high transaminase activity.
G, WERTHEIM, R, ZELEDON, C P, READ
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Although transaminases were identified in animal tissues as early as 1937, very few observations have been made on these systems in parasitic helminths. Daugherty (1952) found that homogenates of the liver fluke, Fasciola hepatica, contained very high transaminase activity.
G, WERTHEIM, R, ZELEDON, C P, READ
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1979
In summary, several branched-chain fatty acids appeared to be competitive inhibitors of GABA-T and non-competitive inhibitors of SSADH. These compounds produce an increase in brain GABA level, and for two of these it was shown that the increase differs among various brain areas. An increase of GABA cannot be obtained by inhibition of SSADH.
L, Ciesielski +8 more
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In summary, several branched-chain fatty acids appeared to be competitive inhibitors of GABA-T and non-competitive inhibitors of SSADH. These compounds produce an increase in brain GABA level, and for two of these it was shown that the increase differs among various brain areas. An increase of GABA cannot be obtained by inhibition of SSADH.
L, Ciesielski +8 more
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Combination of the Suzuki-Miyaura Cross-Coupling Reaction with Engineered Transaminases.
Chemistry, 2018The combination of enzymatic and chemical reaction steps is one important area of research in organic synthesis, preferentially as cascade reactions in one-pot to improve total conversion and achieve high operational stability.
A. Dawood +3 more
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Nature, 1952
IT has previously been reported by Cohen1 that enzyme preparations catalysing the reactions : (1) Alanine + α-ketoglutarate ⇌ glutamate + pyruvate; (2) Aspartate + α-ketoglutarate ⇌ glutamate + oxalo acetate; are also capable of catalysing : (3) Cysteic acid + α-ketoglutarate ⇌ glutamate + sulphopyruvate.
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IT has previously been reported by Cohen1 that enzyme preparations catalysing the reactions : (1) Alanine + α-ketoglutarate ⇌ glutamate + pyruvate; (2) Aspartate + α-ketoglutarate ⇌ glutamate + oxalo acetate; are also capable of catalysing : (3) Cysteic acid + α-ketoglutarate ⇌ glutamate + sulphopyruvate.
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Structural insight into the substrate specificity of PLP fold type IV transaminases
Applied Microbiology and Biotechnology, 2020E. Y. Bezsudnova, V. Popov, K. Boyko
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Application of ω-Transaminases in the Pharmaceutical Industry.
Chemical Reviews, 2018Stephen A Kelly +6 more
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