Results 191 to 200 of about 519,603 (272)

Dichloroacetate Improves Animal Survival, Growth, Neuromuscular Activity, Mitochondrial Stress and Physiology, and Elevated Lactate in C. elegans pdha‐1 and dld‐1 RNAi Models of Pyruvate Dehydrogenase Complex Deficiency (PDCD)

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 6, November 2026.
ABSTRACT Pyruvate dehydrogenase complex (PDHc) deficiency (PDCD) is a primary mitochondrial disorder characterized by neurodevelopmental disability, altered intermediary metabolism, and early mortality. Dichloroacetate (DCA), a pyruvate analog, activates PDHc and remains under clinical investigation for treatment of PDCD.
Cristina Remes   +10 more
wiley   +1 more source

Does the Adoption of Improved Cassava Varieties Boost Productivity in Ghana? The Role of Technology, Management, and Structural Gaps

open access: yesWorld Food Policy, Volume 12, Issue 2, November 2026.
ABSTRACT Agricultural development initiatives in sub‐Saharan Africa have emphasized improved crop varieties as a pathway to food security, resilience, and rural poverty reduction. However, empirical evidence often focuses narrowly on plot‐level outcomes and overlooks whole‐farm effects and the substantial heterogeneity in farmers' management practices,
Kodjo Kondo   +4 more
wiley   +1 more source

A qualitative investigation of the lived experiences of adults with anxiety and related disorders and ADHD: Interconnectedness of symptoms and implications for improving care

open access: yesBritish Journal of Clinical Psychology, Volume 65, Issue 4, Page 925-943, November 2026.
Abstract Background Attention‐deficit/hyperactivity disorder (ADHD) is highly prevalent in adults with anxiety and related disorders (ARDs). Quantitative research on this clinical population is mixed, with some studies suggesting that anxiety is protective against some symptoms of ADHD and others in which co‐occurring ARDs and ADHD are linked to poorer
Arij Alarachi   +3 more
wiley   +1 more source

Adenylation Domain Engineering Enables Biosynthesis of an Improved Polymyxin Antibiotic

open access: yesAngewandte Chemie, Volume 138, Issue 43, 19 October 2026.
To enable incorporation of l‐2‐aminodecanoic acid into polymyxin by fermentation, a single Trp‐to‐Ala substitution is rationally introduced into the adenylation‐domain residue of its nonribosomal peptide synthetase (NRPS) and efficiently switches substrate selectivity. The engineered strain produces biologically active Ada‐polymyxin, demonstrating that
Maximilian Müll   +7 more
wiley   +2 more sources

Mentors' Experiences of Nursing Students' Peer Learning in Clinical Practice: A Systematic Review of Qualitative Studies

open access: yesJournal of Advanced Nursing, Volume 82, Issue 11, Page 9507-9526, November 2026.
ABSTRACT Aim To synthesise the best available evidence on mentors' experiences in mentoring nursing students during peer learning clinical practice. Design A systematic review of qualitative studies. Methods Qualitative or mixed‐methods (with a qualitative component) studies that met the inclusion criteria based on the phenomenon of interest were ...
Sanna Kulojärvi   +6 more
wiley   +1 more source

Real and Apparent Deviations From Rational Choice

open access: yesKyklos, Volume 79, Issue 4, Page 1153-1178, November 2026.
ABSTRACT This paper offers a taxonomy of real and apparent deviations from rationality. The taxonomy is based on three axes of divides—whereas the axes are successive refinements. The outermost‐axis divide delineates “anxiety‐based choices” from “anxiety‐free choices.” Anxiety‐based choices are real deviations such as the Allais and Ellsberg paradoxes ...
Elias L. Khalil
wiley   +1 more source

Home - About - Disclaimer - Privacy