Results 71 to 80 of about 81,808 (266)

Beyond the Outburst: Charting a New Frontier for Understanding and Treating Irritability in Autistic Adults

open access: yesAutism Research, EarlyView.
ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin   +3 more
wiley   +1 more source

Endoscopic surgery versus various open approaches in esthesioneuroblastoma: a systematic review of the literature

open access: yesFrontiers in Oncology
ObjectiveEsthesioneuroblastoma (ENB) is treated using several open surgery (OpS) methods, with or without endoscopic assistance ( ± E-ass) or endoscopic surgery (ES).
Michael Koch   +5 more
doaj   +1 more source

The Unique Roles of Executive Function in Co‐Occurring Psychopathologies in Autism

open access: yesAutism Research, EarlyView.
ABSTRACT Children with autism spectrum disorder (ASD) often experience co‐occurring psychiatric conditions, such as anxiety and attention‐deficit/hyperactivity disorder (ADHD), which significantly impair daily functioning. However, the underlying mechanisms linking these conditions to core ASD features remain poorly understood.
Shing‐Him Ng   +13 more
wiley   +1 more source

Skull-Mimicking Phantoms With Tunable Properties for Transcranial Ultrasound Imaging

open access: yesIEEE Access
Non-invasive transcranial ultrasound imaging for older children and adults is constrained by acoustic effects caused by cranial bone in humans. There is very significant acoustic degradation of wave propagation through the cranium, particularly the ...
Loic Saint-Martin, Kamran Avanaki
doaj   +1 more source

Sustained pharmacodynamic effects of S‐ketamine on cortical excitability and resting‐state brain activity: A randomized, placebo‐controlled trial

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba   +11 more
wiley   +1 more source

Transcranial Magnetic Stimulation as a Translational Biomarker in Early‐Phase Anti‐Seizure Medication Development: A Randomized, Double‐Blind, Placebo‐Controlled Study in Generalized Epilepsy

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba   +7 more
wiley   +1 more source

Transcranial sonography in Parkinson’s disease [PDF]

open access: yesEinstein (São Paulo), 2012
Transcranial sonography has become a useful tool in the differentialdiagnosis of parkinsonian syndromes. This is a non-invasive, low costprocedure. The main finding on transcranial sonography in patientswith idiopathic Parkinson’s disease is an increased
Edson Bor-Seng-Shu   +6 more
doaj  

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

open access: yesEpilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Manual of Transcranial Doppler Ultrasonography

open access: yesKorean Journal of Clinical Laboratory Science
Transcranial Doppler (TCD) ultrasound is a crucial non-invasive tool for assessing cerebral blood flow and is widely used to diagnose and monitor cerebrovascular diseases.
Ho Tae JEONG, Soo Na JEON, Sol HAN
doaj   +1 more source

Novel planning pipeline utilizing the Surgical Theater system for pediatric epilepsy surgery

open access: yesEpilepsia Open, EarlyView.
Abstract Objective Advances in the analysis and collation of radiographic datasets have enhanced presurgical planning for various neurosurgical procedures, including clipping of cerebral aneurysms, surgical resection of tumors, and arteriovenous malformation management.
Lisa B. E. Shields   +4 more
wiley   +1 more source

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