Results 81 to 90 of about 48,751 (307)
Animal Models and Experimental Medicine, EarlyView.In this study, we established a novel mouse model of intracerebral hemorrhage (ICH) by stereotactically injecting thermosensitive PNIPAM hydrogel into the internal capsule to impose localized mechanical stress on the corticospinal tract, which provides a straightforward and reproducible tool for preclinical studies on focal mechanical stress–induced ...
Mingxi Li +11 more
wiley +1 more source
Transcranial Direct Current Stimulation in Neuropathic Pain [PDF]
Journal of Pain & Relief, 2014 Neuropathic pain (NP) is one of the most common problems contributing to suffering and disability worldwide. Unfortunately, NP is also largely refractory to treatments, with a large number of patients continuing to report significant pain even when they are receiving recommended medications and physical therapy.
Ngernyam, Niran +4 more
openaire +2 more sources
, 2019 Tourette syndrome is a neurodevelopmental disorder characterised by motor and phonic tics. For some, tics can be managed using medication and/or forms of behavioural therapy, however, adverse side effects and access to specialist resources can be ...
Jackson, Georgina M. +3 more
core +1 more source
The time course of ineffective sham blinding during low-intensity (1mA) transcranial direct current stimulation [PDF]
, 2019 Studies using transcranial direct current stimulation (tDCS) typically compare an active protocol relative to a shorter sham (placebo) protocol. Both protocols are presumed to be perceptually identical on the scalp, and thus represent an effective method
Buhôt, Larissa +7 more
core +1 more source
Autism Research, EarlyView.ABSTRACT Irritability is a prevalent and impairing feature associated with autism, yet remains poorly understood, particularly in adults. Drawing heavily on insights translated from pediatric and transdiagnostic literatures, we propose that irritability in autistic individuals often reflects a psychophysiological stress or threat response, rooted in a ...
Hsiang‐Yuan Lin +3 more
wiley +1 more source
The Unique Roles of Executive Function in Co‐Occurring Psychopathologies in Autism
Autism Research, EarlyView.ABSTRACT Children with autism spectrum disorder (ASD) often experience co‐occurring psychiatric conditions, such as anxiety and attention‐deficit/hyperactivity disorder (ADHD), which significantly impair daily functioning. However, the underlying mechanisms linking these conditions to core ASD features remain poorly understood.
Shing‐Him Ng +13 more
wiley +1 more source
Transcranial Direct Current Stimulation in Poststroke Hemianopia
Анналы клинической и экспериментальной неврологии, 2020 Introduction. Development of the new approaches to the rehabilitation of patients with poststroke hemianopia is of great importance, given the high prevalence of that disorder and its negative impact on patients quality of life.
Ilya S. Bakulin +5 more
doaj +1 more source
Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that allows the modulation of the excitability and plasticity of the human brain.
Hunold, A. +18 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims This study aimed to investigate a set of pharmacodynamic biomarkers reflecting acute, delayed and sustained central nervous system effects of S‐ketamine, used as a tool compound for rapid‐acting antidepressant activity, with the goal of informing biomarker strategies for delayed antidepressant effects.
Catherine M. K. E. de Cuba +11 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.One‐third of epilepsy patients remain treatment‐resistant, underscoring the need for novel anti‐seizure medications (ASMs) and reliable biomarkers of central target engagement. Cortical hyperexcitability is a hallmark of epilepsy, making excitability a valuable pharmacodynamic biomarker for early‐phase drug development supporting go/no‐go decision ...
Catherine M. E. de Cuba +7 more
wiley +1 more source