Results 91 to 100 of about 27,079 (225)
Tale proteins bind to both active and inactive chromatin [PDF]
, 2014 TALE (transcription activator-like effector) proteins can be tailored to bind to any DNA sequence of choice and thus are of immense utility for genome editing and the specific delivery of transcription activators.
Adams +29 more
core +1 more source
Application of Genome Editing Technology to MicroRNA Research in Mammalians [PDF]
, 2016 Targeted nucleases have recently emerged as a powerful genome editing tool. The ability of introducing targeted, desired changes into mammalian genome makes them an invaluable tool to unravel functions of miRNAs in biology and disease.
Batara, Jennifer, Lu, Biao, Yu, Lei
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Current Strategies of Genomic Modification in Livestock and Applications in Poultry
Journal of Animal Reproduction and Biotechnology, 2019 Since the development of the first genetically-modified mouse, transgenic animals have been utilized for a wide range of industrial applications as well as basic research.
Tae Sub Park
doaj +1 more source
Targeting Human α-Lactalbumin Gene Insertion into the Goat β-Lactoglobulin Locus by TALEN-Mediated Homologous Recombination. [PDF]
PLoS ONE, 2016 Special value of goat milk in human nutrition and well being is associated with medical problems of food allergies which are caused by milk proteins such as β-lactoglobulin (BLG).
Hongmei Zhu +8 more
doaj +1 more source
A secretory kinase complex regulates extracellular protein phosphorylation. [PDF]
, 2015 Although numerous extracellular phosphoproteins have been identified, the protein kinases within the secretory pathway have only recently been discovered, and their regulation is virtually unexplored.
Cui, Jixin +5 more
core +2 more sources
Recent advances and perspectives in crop biofortification
Biologia Plantarum, 2019 The increasing world population and limited amount of land area appropriate for intensive agriculture necessitate high-yield cultivars. The focus is on the enrichment of existing crops deficient in nutrients, which is also called biofortification ...
T. VLČKO, L. OHNOUTKOVÁ
doaj +1 more source
Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity [PDF]
, 2014 Although transcription activator-like effector nucleases (TALENs) can be designed to cleave chosen DNA sequences, TALENs have been shown to have activity against related off-target sequences.
Guilinger, John P. +6 more
core +1 more source
Single-Step Generation of Conditional Knockout Mouse Embryonic Stem Cells
Cell Reports, 2015 Induction of double-strand DNA breaks (DSBs) by engineered nucleases, such as CRISPR/Cas9 or transcription activator-like effector nucleases (TALENs), stimulates knockin of exogenous DNA fragments via homologous recombination (HR).
Matyas Flemr, Marc Bühler
doaj +1 more source
Production and analysis of synthetic Cascade variants [PDF]
, 2020 CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR assoziiert) ist ein adaptives Immunsystem in Archaeen und Bakterien, das fremdes genetisches Material mit Hilfe von Ribonukleoprotein-Komplexen erkennt und zerstört.
Gleditzsch, Daniel
core +1 more source
Molecular Therapy: Nucleic Acids, 2019 The traditional healthcare system is at the doorstep for entering into the arena of molecular medicine. The enormous knowledge and ongoing research have now been able to demonstrate methodologies that can alter DNA coding.
Sikandar Hayat Khan
doaj