Results 171 to 180 of about 11,860 (282)
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, EarlyView.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source
Nuclear Alpha‐Synuclein: Mechanisms and Implications for Synucleinopathies
Movement Disorders, EarlyView.Abstract Alpha‐synuclein (aSyn), historically studied for its synaptic functions and central role in Lewy body pathology, is emerging as a protein with significant nuclear activities relevant to Parkinson's disease (PD) and related synucleinopathies. Recent advances reveal that aSyn dynamically localizes to neuronal nuclei in both health and disease ...
Tiago Fleming Outeiro, David J. Koss
wiley +1 more source
The Journal of Pathology, EarlyView.Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou +3 more
wiley +1 more source
PLANTS, PEOPLE, PLANET, EarlyView.Climate extremes threaten the sustainability of cranberry production, a culturally and economically important North American crop. This study demonstrates that wild cranberries (Vaccinium oxycoccos) harbor genetic variation that may enhance cold stress resilience when introduced into cultivated cranberry through hybridization.
Audrey Dickinson +5 more
wiley +1 more source
Adverse effects of grapevine trunk diseases on canes produced from infected rootstock mother blocks
Pest Management Science, EarlyView.High incidences of GTD pathogens in rootstock mother vine heads, with Phaeomoniella chlamydospora and Diplodia seriata affecting cane physiology and quality. One‐year‐old canes harbor systemic inoculum, highlighting the need for careful monitoring and management.
Wynand Jacobus van Jaarsveld +5 more
wiley +1 more source
Functional divergence and regulatory network of the type VI secretion system in <i>Vibrio parahaemolyticus</i>. [PDF]
J BacteriolWang X, Yao P, Liu L, Zhang Y.
europepmc +1 more source
Pest Management Science, EarlyView.Tebuconazole‐resistant isolates overexpress CYP51 and, when tested at field rates, did not reduce ABS severity, whereas difenoconazole and mefentrifluconazole remained effective. Abstract BACKGROUND Alternaria brown spot (ABS), caused by Alternaria spp., is an important disease affecting mandarin production in several citrus‐growing regions worldwide ...
Thiago de Aguiar Carraro +7 more
wiley +1 more source