Generation of knockout rabbits using transcription activator-like effector nucleases
Cell Regeneration, 2014 Zinc-finger nucleases and transcription activator-like effector nucleases are novel gene-editing platforms contributing to redefine the boundaries of modern biological research. They are composed of a non-specific cleavage domain and a tailor made DNA-binding module, which enables a broad range of genetic modifications by inducing efficient DNA double ...
Yu Wang +12 more
openalex +4 more sources
TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES-AMAZING TOOL FOR GENOME EDITING [PDF]
OnLine Journal of Biological Sciences, 2013 Transcription Activator-Like Effector Nucleases (TALENs) are used to cut specific target DNA sequence in order to knock out a gene or to change its sequence. They are formed by the fusion of TALE protein serving as DNA binding domain along with non-specific DNA cleaving nucleases. Its specificity towards DNA bases in the target sequence is derived from
Singh
openalex +3 more sources
Gene Editing of the Follicle-Stimulating Hormone Gene to Sterilize Channel Catfish, Ictalurus punctatus, Using a Modified Transcription Activator-like Effector Nuclease Technology with Electroporation. [PDF]
Biology (Basel), 2023 Qin G +8 more
europepmc +3 more sources
Targeted Mutagenesis of the Tomato PROCERA Gene Using Transcription Activator-Like Effector Nucleases [PDF]
Plant Physiology, 2014 Transcription activator-like effector nucleases successfully generate a heritable tomato mutant.
Vai S. Lor +4 more
openalex +3 more sources
Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats. [PDF]
PLoS One, 2016 Liška F +12 more
europepmc +3 more sources
Transcription activator-like effector nuclease (TALEN)-mediated female-specific sterility in the silkworm, Bombyx mori. [PDF]
Insect Mol Biol, 2014 Engineering sex-specific sterility is critical for developing transgene-based sterile insect technology. Targeted genome engineering achieved by customized zinc-finger nuclease, transcription activator-like effector nuclease (TALEN) or clustered, regularly interspaced, short palindromic repeats/Cas9 systems has been exploited extensively in a variety ...
Xu J +7 more
europepmc +6 more sources
Transcription activator-like effector nuclease (TALEN)-mediated gene correction in integration-free β-thalassemia induced pluripotent stem cells. [PDF]
J Biol Chem, 2013 Ma N +11 more
europepmc +3 more sources
Transcription activator-like effector nuclease (TALEN) as a promising diagnostic approach for COVID-19. [PDF]
Expert Rev Mol Diagn, 2022 Behboudi E +4 more
europepmc +3 more sources
Generation of gene disruptions by transcription activator-like effector nucleases (TALENs) in Xenopus tropicalis embryos [PDF]
Cell & Bioscience, 2013 Abstract Transcription activator-like effector nucleases (TALENs) are novel engineered DNA nucleases, and have been proven to be effective for gene specific targeting in various species. Recently we reported gene disruptions in Xenopus embryos by using TALENs.
Yong Lei +4 more
openalex +4 more sources
High throughput synthesis of transcription activator–like effector nucleases (TALENs) [PDF]
Science-Business eXchange, 2012 openalex +3 more sources