Results 51 to 60 of about 11,860 (282)
JOR Spine, 2023 There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a ...
Ze‐Yu Lu +6 more
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PLoS ONE, 2012 Zinc Finger Nucleases (ZFNs) made by Context-Dependent Assembly (CoDA) and Transcription Activator-Like Effector Nucleases (TALENs) provide robust and user-friendly technologies for efficiently inactivating genes in zebrafish. These designer nucleases bind to and cleave DNA at particular target sites, inducing error-prone repair that can result in ...
Moore, Finola E. +8 more
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Molecular Therapy: Nucleic Acids, 2014 Although noncancerous immortalized cell lines have been developed by introducing genes into human and murine somatic cells, such cell lines have not been available in large domesticated animals like pigs.
JoonHo Moon +6 more
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Engineering Designer Transcription Activator‐‐Like Effector Nucleases (TALENs) by REAL or REAL‐Fast Assembly [PDF]
Current Protocols in Molecular Biology, 2012 AbstractEngineered transcription activator–like effector nucleases (TALENs) are broadly useful tools for performing targeted genome editing in a wide variety of organisms and cell types including plants, zebrafish, C. elegans, rat, human somatic cells, and human pluripotent stem cells.
Deepak, Reyon +4 more
openaire +2 more sources
A Current Approach in Animal Breeding: CRISPR/Cas9 Genome Modification System
Turkish Journal of Agriculture: Food Science and Technology, 2016 Genome modifications include potential about providing significant advantages on increasing yield performance and developing resistance to diseases. Gene editing methods that provides silencing or expressing of a gene which is an individual already has ...
Fatih Bilgi +2 more
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Immunodeficient Rabbit Models: History, Current Status and Future Perspectives
Applied Sciences, 2020 Production of immunodeficient (ID) models in non-murine animal species had been extremely challenging until the advent of gene-editing tools: first zinc finger nuclease (ZFN), then transcription activator-like effector nuclease (TALEN), and most recently
Jun Song +7 more
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Recent advances in genetically modified large-animal models of human diseases
BIO Integration, 2022 Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics.
Jing Zhang, Xiaoyue Sun, Chunwei Cao
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Molecules, 2018 Gene therapies, including genome editing, RNAi, anti-sense technology and chemical DNA editing are becoming major methods for the treatment of genetic disorders.
Siddhant Sethi +2 more
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Genetics and Molecular Biology, 2014 Engineered nucleases such as zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN) are one of the most promising tools for modifying genomes.
Arildo Nerys-Junior +7 more
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The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. [PDF]
PLoS Genetics, 2016 Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of how these variants alter gene function.
Gang Li +7 more
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