Results 71 to 80 of about 27,079 (225)
Recent advances in genetically modified large-animal models of human diseases
BIO Integration, 2022 Large-animal models show greater advantages than rodents in recapitulating human genetic diseases, primarily because of their higher similarity to humans in terms of anatomy, physiology and genetics.
Jing Zhang, Xiaoyue Sun, Chunwei Cao
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Human lactoferrin efficiently targeted into caprine beta-lactoglobulin locus with transcription activator-like effector nucleases [PDF]
Asian-Australasian Journal of Animal Sciences, 2016 To create genetically modified goat as a biopharming source of recombinant human lacotoferrin (hLF) with transcription activator-like effector nucleases.TALENs and targeting vector were transferred into cultured fibroblasts to insert hLF cDNA in the goat beta-lactoglobulin (BLG) locus with homology-directed repair.
Meng-Ming Zhu +8 more
openaire +3 more sources
DNA Methylation Affects the Efficiency of Transcription Activator-Like Effector Nucleases-Mediated Genome Editing in Rice [PDF]
Frontiers in Plant Science, 2017 Genome editing in plants becomes popular since the advent of sequence-specific nucleases (SSNs) that are simple to set up and efficient in various plant species. Although transcription activator-like effector nucleases (TALENs) are one of the most prevalent SSNs and have a potential to provide higher target specificity by their dimeric property, TALENs
Seiichi Toki +4 more
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CRISPR-Cas systems in prokaryotes [PDF]
, 2015 Prokaryotic organisms possess numerous strategies that enable survival in hostile conditions. Among others, these conditions include the invasion of foreign nucleic acids such as bacteriophages and plasmids.
Burmistrz, Michał, Pyrć, Krzysztof
core +1 more source
Molecules, 2018 Gene therapies, including genome editing, RNAi, anti-sense technology and chemical DNA editing are becoming major methods for the treatment of genetic disorders.
Siddhant Sethi +2 more
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Design, evaluation, and screening methods for efficient targeted mutagenesis with transcription activator‐like effector nucleases in medaka [PDF]
Development, Growth & Differentiation, 2013 Genome editing using engineered nucleases such as transcription activator‐like effector nucleases (TALENs) has become a powerful technology for reverse genetics. In this study, we have described efficient detection methods for TALEN‐induced mutations at endogenous loci and presented guidelines of TALEN design for efficient targeted mutagenesis in ...
Ansai Satoshi +6 more
openaire +3 more sources
Genetics and Molecular Biology, 2014 Engineered nucleases such as zinc finger nucleases (ZFN) and transcription activator-like effector nucleases (TALEN) are one of the most promising tools for modifying genomes.
Arildo Nerys-Junior +7 more
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The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1. [PDF]
PLoS Genetics, 2016 Understanding the implications of genome-wide association studies (GWAS) for disease biology requires both identification of causal variants and definition of how these variants alter gene function.
Gang Li +7 more
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Chapter 9 Gene Drive Strategies for Population Replacement [PDF]
, 2016 Gene drive systems are selfish genetic elements capable of spreading into a population despite a fitness cost. A variety of these systems have been proposed for spreading disease-refractory genes into mosquito populations, thus reducing their ability to ...
Akbari, Omar S, Marshall, John M
core +1 more source
Bio-Protocol, 2015 Transcription activator-like effectors (TALEs) are naturally occurring proteins secreted by the plant pathogen, Xanthomonas, and fused to the Fok1 endonuclease to generate TALE nucleases (TALENs).
Christy Hammack
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