Results 321 to 330 of about 15,541,955 (379)

The Transcription Factor Islet-1 Regulates Diabetes-Induced Inner Blood-Retinal Barrier Disruption. [PDF]

Invest Ophthalmol Vis Sci
Wang N, Yao F, Xu W, Feng T, Li Z, Zhang Q, Wang W, Zhang X, Lei W, Zheng G, Xu Y, Liu D, Zhu Y, Xia X, Xiong S.   +14 more
europepmc   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

The SAMD1 transcription factor coordinates hematopoietic lineage differentiation and H3K4 methylation status. [PDF]

Blood Adv
Schaefer MA, Gomez SL, Dogiparthi VR, Zhou Y, Roy P, Ray S, Chee L, Brahma S, Liefke R, Hewitt KJ.   +9 more
europepmc   +1 more source

Lactoferrin treatment activates acetylcholinesterase, decreasing acetylcholine levels in non‐small cell lung cancer (NSCLC) cell culture supernatants, inhibiting cell survival

FEBS Open Bio, EarlyView.
Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel, Caroline Wozniak, Aya Sabri, Ben Haddad, Brooke Lopo, Alvaro Cobos, Sarah Sarofim, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evans   +9 more
wiley   +1 more source

Cell fate acquisition and reprogramming by the proneural transcription factor ASCL1. [PDF]

Open Biol
Lundie-Brown J, Puletti F, Philpott A, Azzarelli R.   +3 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Transcription factor Yin-Yang 1 governs cardiac metabolic reprogramming in response to exercise or pathological stress. [PDF]

Am J Physiol Heart Circ Physiol
Zhang M, Peng Z, Ping H, Li Z, Liu JJ, Liu S, Feng N.   +6 more
europepmc   +1 more source

Leveraging transcription factor physical proximity for enhancing gene regulation inference. [PDF]

Bioinformatics
Huang X, Hullur AR, Jafari E, Shridhar K, Zhou M, Mackie K, Huang K, Wang Y.   +7 more
europepmc   +1 more source