Results 101 to 110 of about 9,751,730 (314)
Walking, hopping and jumping: a model of transcription factor dynamics on DNA [PDF]
, 2011 We present a model of how transcription factors scan DNA to find their specific binding sites. Following the classical work of Winter et al. (1981), our model assumes two modes of transcription factor dynamics.
Barnes, David J., Chu, Dominique
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Using temporal correlation in factor analysis for reconstructing transcription factor activities [PDF]
, 2008 Two-level gene regulatory networks consist of the transcription factors (TFs) in the top level and their regulated genes in the second level. The expression profiles of the regulated genes are the observed high-throughput data given by experiments such ...
Wernisch, Lorenz +3 more
core +1 more source
Transcription Factors in Biocontrol Fungi
Journal of FungiTranscription factors are extensively found in fungi and are involved in the regulation of multiple biological processes, including growth, development, conidiation, morphology, stresses tolerance, and virulence, as well as the production of secondary ...
Han-Jian Song +4 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Diagnostic and Prognostic Implications of Cancer Stem Cell Transcription Factors
, 2023 Cancer stem cells (CSCs) are a subpopulation of malignant cells with self-renewing capacity, hence being vital in the areas of tumour initiation and progression, therapeutic resistance, and tumour relapse following treatment.
Islam, F, Gopalan, V, Patil, S
core +1 more source
OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts
Cell Reports, 2017 SOX2 and OCT4, in conjunction with KLF4 and cMYC, are sufficient to reprogram human fibroblasts to induced pluripotent stem cells (iPSCs), but it is unclear if they function as transcriptional activators or as repressors.
Santosh Narayan +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Chapter 5 Synthesis and Evaluation of Polyamide-Isoxazolidine
, 2014 Pyrrole-Imidazole hairpin polyamides are a cell-permeable class of DNA-binding small molecules that are able to access chromatin and disrupt the transcription factor-DNA binding interface, thereby downregulating endogenous gene expression in human ...
Conjugates Artificial +1 more
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