Results 141 to 150 of about 9,751,730 (314)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Smad transcription factors as mediators of 7 transmembrane G protein-coupled receptor signalling [PDF]
The Smad transcription factors are well known for their role at the core of transforming growth factor-β (TGF-β) signalling. However, recent evidence shows that the Smad transcription factors play a vital role downstream of other classes of receptors ...
Zhang, Ruizhi +4 more
core +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Transcription factors read epigenetics
, 2017 Many homeodomain transcription factors can bind methylated ...
Timothy R. Hughes, Samuel A. Lambert
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Summary of DEGs related to transcription factors.
, 2016 (A) Up-regulated unigenes related to transcription factors. (B) Down-regulated unigenes related to transcription factors.
Yunliu Fu (3144369) +7 more
core +1 more source
REGULATORY TRANSCRIPTION FACTORS MAY PARTICIPATE IN POST-INITIATION CONTROL OF TRANSCRIPTION
Вавиловский журнал генетики и селекции, 2015 Sequence-specific (regulatory) transcription factors selectively regulate the transcription levels of different sets of eukaryotic genes depending on cell type, developmental stage, and external signals. Recruitment of the RNA-polymerase II transcription
V. M. Merkulov, T. I. Merkulova
doaj
Transcriptional regulation of suberin and its response to the environment
Xibei zhiwu xuebao[Objective] Suberin is a polyester type biopolymer that specifically deposits in tissues such as the endodermis, periderm, seed coat, and wound epidermis of plants.
ZHOU Yue, AN Yongping, MA Rong, WANG Pei
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source