Results 181 to 190 of about 1,455,915 (219)

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Short activation domains control chromatin association of transcription factors. [PDF]

Elife
Fan VB, Abidi AA, Graham TGW, Darzacq X, Staller MV.   +4 more
europepmc   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

The Structure, Classification, Functional Diversity and Regulatory Mechanism of Plant C2H2 Transcription Factors. [PDF]

Biology (Basel)
Ma J, Zhang X, Jiang S, Fei S, Kong L, Pan M, Ma W, Ren W.   +7 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Importin-9 recognizes the winged-helix fold of ETS transcription factors to mediate nuclear import. [PDF]

Proc Natl Acad Sci U S A
McConville M, Lankford K, Bernardes NE, Walterscheid A, Valadez C, Niesman A, Chook YM, Liszczak G.   +7 more
europepmc   +1 more source

Identification and characterization of GRAS transcription factors in <i>Panax quinquefolius</i> and their potential roles in cold tolerance. [PDF]

Front Plant Sci
Lian J, Yao K, Wang Y, Wang Y, Lei X, Zhang J, Di P.   +6 more
europepmc   +1 more source

How Polyphenol Metabolites Spatiotemporally Reprogram Transcription Factors and Human Proteostasis: A Metabolite-Centric Framework. [PDF]

Curr Issues Mol Biol
Lastra JMP, Andrés CMC, Munguira EB, Juan CA, Pérez Lebeña E.   +4 more
europepmc   +1 more source

A systematic guide for identifying transcription factors that directly regulate the expression of a gene of interest. [PDF]

Genome Res
Bates AD, Grzela D, Studzian M, Brennan L, Williams M, Fawcett C, Hammond B, Grewal M, Ratajewski M, Pulaski L, McClurg UL.   +10 more
europepmc   +1 more source